Cytoskeletal architecture of isolated mitotic spindle with special reference to microtubule-associated proteins and cytoplasmic dynein. [PDF]
, 1985 Nobutaka Hirokawa +2 more
openalex +1 more source
Microtubule Organization and Microtubule-Associated Proteins (MAPs)
, 2016 Dendrites have a unique microtubule organization. In vertebrates, dendriticmicrotubules are organized in antiparallel bundles, oriented with their plusends either pointing away or toward the soma. The mixed microtubule arrayscontrol intracellular trafficking and local signaling pathways, and are essential fordendrite development and function.
Tortosa Binacua, E. +2 more
openaire +3 more sources
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
Frontiers in ImmunologyAggregation of high-affinity IgE receptors (FcϵRIs) on granulated mast cells triggers signaling pathways leading to a calcium response and release of inflammatory mediators from secretory granules.
Vadym Sulimenko +7 more
doaj +1 more source
Immunocytochemical localization of tubulin and microtubule-associated protein 2 during the development of hippocampal neurons in culture [PDF]
, 1986 Alfredo Cáceres, GA Banker, LI Binder
openalex +1 more source
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Comparison of the effects of microtubule-associated protein 2 and tau on the packing density of in vitro assembled microtubules. [PDF]
, 1987 Mark M. Black
openalex +1 more source
The 68,000-Dalton Neurofilament-Associated Polypeptide is a Component of Nonneuronal Cells and of Skeletal Myofibrils [PDF]
, 1980 Purified preparations of 10-nm neurofilaments from rat spinal cord and bovine or porcine brain contain a predominant 68,000-dalton polypeptide. This polypeptide is also a major component of the neurofilaments that copurify with brain tubulin isolated by ...
Asai, David J. +2 more
core
Advanced Science, EarlyView.This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu +7 more
wiley +1 more source