Characterization and functional analysis of the potato pollen-specific microtubule-associated protein SBgLR in tobacco. [PDF]
PLoS ONE, 2013 Microtubule-associated proteins play a crucial role in the regulation of microtubule dynamics, and are very important for plant cell and organ development.
Chen Liu, Xin Qi, Qian Zhao, Jingjuan Yu
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The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules
eLife, 2022 Cells increase microtubule dynamics to make large rearrangements to their microtubule cytoskeleton during cell division. Changes in microtubule dynamics are essential for the formation and function of the mitotic spindle, and misregulation can lead to ...
Thomas S McAlear, Susanne Bechstedt
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Autoregulatory control of microtubule binding in doublecortin-like kinase 1
eLife, 2021 The microtubule-associated protein, doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and is a prominent therapeutic target for kinase inhibitors. The physiological roles of DCLK1 kinase activity and how it is regulated remain
Regina L Agulto +8 more
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Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]
, 2016 Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Babić Leko, Mirjana +11 more
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eLife, 2015 The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation.
Binyam Mogessie +3 more
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Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]
, 2001 Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen +67 more
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Microtubules and Microtubule-Associated Proteins [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by ...
Holly V, Goodson, Erin M, Jonasson
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CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast
Biology Open, 2019 Microtubules in the mitotic spindle are organised by microtubule-associated proteins. In the late stage of mitosis, spindle microtubules are robustly organised through bundling by the antiparallel microtubule bundler Ase1/PRC1. In early mitosis, however,
Hirohisa Ebina, Liang Ji, Masamitsu Sato
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NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]
, 2013 Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
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