Results 191 to 200 of about 1,320,439 (381)

Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C. [PDF]

, 2019
The unidirectional and opposite-polarity microtubule-based motors, dynein and kinesin, drive long-distance intracellular cargo transport. Cellular observations suggest that opposite-polarity motors may be coupled.
Dickey, Andrea M, Dzieciatkowska, Monika, Harper, J Wade, Kendrick, Agnieszka A, Reck-Peterson, Samara L, Redwine, William B, Tran, Phuoc Tien, Vaites, Laura Pontano   +7 more
core  

NIR Driven Pd/Cerium Oxide Nano‐Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy

Advanced Science, EarlyView.
In vivo SALI therapy is achieved by scavenging intracellular ROS levels, downregulating inflammatory factors expression levels, inducing macrophage M2 directional polarization, and activating Keap1/Nrf‐2/HO‐1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation, and promote liver tissue repair. Abstract Sepsis
Tao Qin, Lian Qin, Yang Zhao, Yin Chen, Qianyue Liu, Xiaoguang Lin, Yongfeng Lan, Yaohui Huang, Yan Liu, Ke Zhang, Lifan Pan, Jiaxiao Li, Kunpeng Duan, Hao Liang, Mingjing Yin, Guiyang Fan, Lian Liu, Yu Deng, Lin Liao, Danke Su, Ming Gao, Junyu Lu   +21 more
wiley   +1 more source

Purification and characterization of a 190-kD microtubule-associated protein from bovine adrenal cortex. [PDF]

, 1986
Hiromu Murofushi, Susumu Kotani, Hiroyuki Aizawa, Shin‐ichi Hisanaga, Nobutaka Hirokawa, Hikoichi Sakai   +5 more
openalex   +1 more source

Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. [PDF]

, 2019
Ischemic injury to white matter tracts is increasingly recognized to play a key role in age-related cognitive decline, vascular dementia, and Alzheimer's disease.
Bitan, Gal, Charreton, Malena, Dutta, Suman, Hayden, Eric Y, Hinman, Jason D, Jiang, Lin, Joy, Mary Teena, Komuro, Yutaro, Li, Zizheng, MacKenzie-Graham, Allan, Nunez, Stefanie, Oberoi, Mandavi, Putman, Jennifer, Shin, Woo Shik   +13 more
core  

Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity

Advanced Science, Volume 12, Issue 28, July 24, 2025.
In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang, Jiahui Zou, Yaoming Jin, Chenjun Jiang, Shaoyu Tu, Tong Chen, Jinli Guo, Yanqing Cheng, Meilin Jin, Huanchun Chen, Hongbo Zhou   +10 more
wiley   +1 more source

Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3

EBioMedicine, 2020
Background: Chromosomal instability plays an important part in cancer, but its genetic basis in liver tumorigenesis remains largely unclear. We aimed to characterize the mechanistic significance and clinical implication of mitotic regulator microtubule ...
Jing Zhang, Jun-Zhe Huang, Yan-Quan Zhang, Xiang Zhang, Liu-Yang Zhao, Chuan-Gen Li, Yun-Fei Zhou, Hong Wei, Jun Yu   +8 more
doaj  

Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension. [PDF]

Int J Mol Sci, 2023
Hu J, Sha W, Yuan S, Wu J, Huang Y.
europepmc   +1 more source

Regulation of a high molecular weight microtubule-associated protein in PC12 cells by nerve growth factor. [PDF]

, 1983
Lloyd A. Greene, Ronald K.H. Liem, M. L. Shelanski   +2 more
openalex   +1 more source

Role of Tunneling Nanotubes in Arachidonic Acid Transfer and Macrophage Function Reprogramming in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
Tunneling nanotubes facilitate the transfer of long‐chain fatty acids, primarily arachidonic acid, from tumor cells to macrophages, leading to lipid accumulation and activation of the PI3K‐Akt pathway. This drives a shift from the anti‐tumor CD5L⁺ phenotype to a pro‐tumor TREM2⁺ phenotype.
Meiru Chen, Shangyumeng Zhao, Xiaoli Xie, Jiaqi Wang, Miao Su, Lixian Zhang, Ruolin Cui, Dongqiang Zhao   +7 more
wiley   +1 more source

Interactions between neurofilaments and microtubule-associated proteins: a possible mechanism for intraorganellar bridging. [PDF]

, 1982
J.F. Leterrier, Ronald K.H. Liem, M. L. Shelanski   +2 more
openalex   +1 more source