Mitogen‐activated‐protein‐kinase‐catalyzed phosphorylation of microtubule‐associated proteins, microtubule‐associated protein 2 and microtubule‐associated protein 4, induces an alteration in their function [PDF]
European Journal of Biochemistry, 1992 Mitogen‐activated protein kinase (MAPK), a serine/threonine‐specific protein kinase which is generally activated by stimulation with various growth factors and phorbol esters, utilizes microtubule‐associated protein (MAP) 2 as a good substrate in vitro.
Hiromu Murofushi +6 more
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, 2018 The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
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Perturbing Microtubule Integrity Blocks AMP-Activated Protein Kinase-Induced Meiotic Resumption in Cultured Mouse Oocytes [PDF]
, 2012 The oocyte meiotic spindle is comprised of microtubules (MT) that bind chromatin and regulate both metaphase plate formation and karyokinesis during meiotic maturation; however, little information is known about their role in meiosis reinitiation.
Downs, Stephen, Ya, Ru
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Nature Communications, 2017 Dynein is a microtubule motor the motility of which is affected by the microtubule-associated protein She1. Here, the authors show that She1 alters dynein stepping behavior and increases its microtubule affinity through simultaneous interactions with the
Kari H. Ecklund +5 more
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Phase separation of the microtubule-associated protein tau
Essays in Biochemistry, 2022 Abstract The aggregation and misfolding of the neuronal microtubule-associated protein tau is closely linked to the pathology of Alzheimer’s disease and several other neurodegenerative diseases. Recent evidence suggest that tau undergoes liquid–liquid phase separation in vitro and forms or associates with membrane-less organelles in ...
Pijush Chakraborty, Markus Zweckstetter
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The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells [PDF]
, 2002 Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating β-catenin levels in the Wnt signaling pathway, the APC protein is ...
Mackie, John B. +4 more
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Microtubule-Associated Protein 2 Expression in Canine Glioma
Frontiers in Veterinary Science, 2019 Canine glioma is considered a potential model for human glioma, with recent studies of occurrence, therapy, and reclassification supporting the value of the canine model.
Elena Alina Demeter +4 more
doaj +1 more source
CKAP2 ensures chromosomal stability by maintaining the integrity of microtubule nucleation sites. [PDF]
PLoS ONE, 2013 Integrity of the microtubule spindle apparatus and intact cell division checkpoints are essential to ensure the fidelity of distributing chromosomes into daughter cells.
Chanelle M Case +6 more
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Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism [PDF]
, 2014 Defects in centrosome, centrosomal-associated and spindle-associated proteins are the most frequent cause of primary microcephaly (PM) and microcephalic primordial dwarfism (MPD) syndromes in humans.
A Abrieu +64 more
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Cancer Cell International, 2020 Background Cervical cancer (CC) is one of the most common female malignancies over the world. Microtubule-associated protein 7 (MAP7) belongs to the family of microtubule-associated proteins (MAPs) which involve in microtubule dynamics and are critical ...
Ning Tang +5 more
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