Results 41 to 50 of about 189,832 (159)

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity

eLife, 2020
The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is
Liu He, Robbelien Kooistra, Ravi Das, Ellen Oudejans, Eric van Leen, Johannes Ziegler, Sybren Portegies, Bart de Haan, Anna van Regteren Altena, Riccardo Stucchi, AF Maarten Altelaar, Stefan Wieser, Michael Krieg, Casper C Hoogenraad, Martin Harterink   +14 more
doaj   +1 more source

Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines

Research and Reports in Urology, 2017
Jian Yang,1,2,* Yang Yu,1,* Wei Liu,2 Zhi Li,2 Zhongqing Wei,2 Rongjiang Jiang1,2 1The Second Clinical Medical College of Nanjing Medical University, 2Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu ...
Yang J, Yu Y, Liu W, Liu W, Li Z, Wei ZQ, Jiang R   +6 more
doaj  

Dystrophin is a microtubule-associated protein [PDF]

Journal of Cell Biology, 2009
Cytolinkers are giant proteins that can stabilize cells by linking actin filaments, intermediate filaments, and microtubules (MTs) to transmembrane complexes. Dystrophin is functionally similar to cytolinkers, as it links the multiple components of the cellular cytoskeleton to the transmembrane dystroglycan complex.
Prins, Kurt W., Humston, Jill L., Mehta, Amisha, Tate, Victoria, Ralston, Evelyn, Ervasti, James M.   +5 more
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Multifunctional Microtubule-Associated Proteins in Plants [PDF]

Frontiers in Plant Science, 2016
Microtubules (MTs) are involved in key processes in plant cells, including cell division, growth and development. MT-interacting proteins modulate MT dynamics and organization, mediating functional and structural interaction of MTs with other cell structures.
Jana eKrtková, Jana eKrtková, Martina eBenáková, Martina eBenáková, Katerina eSchwarzerova   +4 more
openaire   +3 more sources

Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3

EBioMedicine, 2020
Background: Chromosomal instability plays an important part in cancer, but its genetic basis in liver tumorigenesis remains largely unclear. We aimed to characterize the mechanistic significance and clinical implication of mitotic regulator microtubule ...
Jing Zhang, Jun-Zhe Huang, Yan-Quan Zhang, Xiang Zhang, Liu-Yang Zhao, Chuan-Gen Li, Yun-Fei Zhou, Hong Wei, Jun Yu   +8 more
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Pathogenic Tau Protein Species: Promising Therapeutic Targets for Ocular Neurodegenerative Diseases

Journal of Ophthalmic & Vision Research, 2019
Tau is a microtubule-associated protein, which is highly expressed in the central nervous system as well as ocular neurons and stabilizes microtubule structure.
Mohammad Amir Mishan, Mozhgan Rezaei Kanavi, Koorosh Shahpasand, Hamid Ahmadieh   +3 more
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DJ-1 can inhibit microtubule associated protein 1 B formed aggregates

Molecular Neurodegeneration, 2011
Background Abnormal accumulation and aggregation of microtubule associated proteins (MAPs) plays an important role in the pathogenesis of neurodegenerative diseases. Loss-of-function mutation of DJ-1/Park7 can cause early onset of PD.
Ding Jianqing, Xiong Ran, Wang Xinyi, Tan Yuyan, Guo Qianqian, Zhang Yu, Zhang Shi, Wang Zhiquan, Chen Shengdi   +8 more
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CLASP-mediated competitive binding in protein condensates directs microtubule growth

Nature Communications
Microtubule organization in cells relies on targeting mechanisms. Cytoplasmic linker proteins (CLIPs) and CLIP-associated proteins (CLASPs) are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here, we reveal that
Xuanyan Jia, Leishu Lin, Siqi Guo, Lulu Zhou, Gaowei Jin, Jiayuan Dong, Jinman Xiao, Xingqiao Xie, Yiming Li, Sicong He, Zhiyi Wei, Cong Yu   +11 more
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Phosphorylation of MAP18 by MPK6 orchestrates microtubule reorganization in Arabidopsis during adaptation to salt stress

Cell Reports
Summary: Plants adapt to salt stress by modulating growth, but the signaling mechanisms remain unclear. Cortical microtubules exhibit biphasic reorganization (disassembly followed by reassembly) under salinity.
Mingzhi Zheng, Liyuan Xu, Takashi Hashimoto, Che Wang, Ying Fu, Lei Zhu   +5 more
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Big Tau: Structure, Evolutionary Divergence, and Emerging Roles in Cytoskeletal Dynamics and Tauopathies

Cells
Tau proteins are microtubule-associated proteins that regulate axonal structure, dynamics, and transport, and their dysregulation underlies several neurodegenerative diseases.
Itzhak Fischer, Peter W. Baas
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