Interaction of estramustine phosphate with microtubule‐associated proteins [PDF]
FEBS Letters, 1985 We have reported [(1984) Cancer Res., in press] that estramustine phosphate inhibits microtubule assembly and disassembled preformed microtubules. We now present evidence that estramustine phosphate inhibits microtubule assembly by binding to the microtubule‐associated proteins.
Margareta Wallin +2 more
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Evidence that griseofulvin binds to a microtubule associated protein [PDF]
FEBS Letters, 1977 We have recently shown that the anti-mitotic drug, griseofulvin, inhibits assembly of brain microtubules in vitro [l] . Similar data have been presented by Weber et al. [2] . Our earlier experiments indicated that griseofulvin inhibits microtubule assembly by preventing the association between tubulin and the microtubule associated proteins (MAPS ...
Roobol, A, Gull, K, Pogson, I
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Atypical, non-standard functions of the microtubule associated Tau protein
Acta Neuropathologica Communications, 2017 Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau’s role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and ...
Ioannis Sotiropoulos +15 more
doaj +1 more source
Microtubule-associated type II protein kinase A is important for neurite elongation. [PDF]
PLoS ONE, 2013 Neuritogenesis is a process through which neurons generate their widespread axon and dendrites. The microtubule cytoskeleton plays crucial roles throughout neuritogenesis.
Yung-An Huang +5 more
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Directional instability of microtubule transport in the presence of kinesin and dynein, two opposite polarity motor proteins. [PDF]
, 1992 Kinesin and dynein are motor proteins that move in opposite directions along microtubules. In this study, we examine the consequences of having kinesin and dynein (ciliary outer arm or cytoplasmic) bound to glass surfaces interacting with the same ...
Brown, D, Malik, F, Vale, RD
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Bio-Protocol, 2018 In this protocol, we describe a simple microscopy-based method to assess the interaction of a microtubule-associated protein (MAP) with microtubules. The interaction between MAP and microtubules is typically assessed by a co-sedimentation assay, which ...
Yili Zhu, Weimin Tan, Wei-Lih Lee
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Microtubule-associated Protein 1S, a Short and Ubiquitously Expressed Member of the Microtubule-associated Protein 1 Family [PDF]
Journal of Biological Chemistry, 2005 The related high molecular mass microtubule-associated proteins (MAPs) MAP1A and MAP1B are predominantly expressed in the nervous system and are involved in axon guidance and synaptic function. MAP1B is implicated in fragile X mental retardation, giant axonal neuropathy, and ataxia type 1.
Friedrich Propst +4 more
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MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. [PDF]
, 2018 Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood.
Ma, Le +3 more
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Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
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