Results 71 to 80 of about 296,624 (347)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Salix SmSPR1 Involved in Light-Regulated Cell Expansion by Modulating Microtubule Arrangement

Frontiers in Cell and Developmental Biology, 2019
Light signaling and cortical microtubule (MT) arrays are essential to the anisotropic growth of plant cells. Microtubule-associated proteins (MAPs) function as regulators that mediate plant cell expansion or elongation by altering the arrangements of the
Liu Xiaoxia, Jianguo Zhang, Jianguo Zhang, Jianguo Zhang, Sui Jinkai, Luo Ying, Rao Guodong   +6 more
doaj   +1 more source

Alignment between PIN1 Polarity and Microtubule Orientation in the Shoot Apical Meristem Reveals a Tight Coupling between Morphogenesis and Auxin Transport [PDF]

, 2010
Morphogenesis during multicellular development is regulated by intercellular signaling molecules as well as by the mechanical properties of individual cells.
A Peaucelle, A. C Newell, A. J Fleming, A. R Paredez, A. R Paredez, C Lloyd, Carolyn Ohno, D Reinhardt, D Reinhardt, D. D Fisher, E. J Chapman, E. M Bayer, Elliot M. Meyerowitz, F Corson, F. A Ditengou, G. J Mitchison, G. V Reddy, H Jonsson, Henrik Jönsson, J Craft, J Friml, J Marc, J Petrasek, J. A Raven, Jan Traas, K Okada, M. G Heisler, Magalie Uyttewaal, Marcus G. Heisler, N Geldner, N. C Shaner, O Grandjean, O Hamant, Olivier Hamant, Ottoline Leyser, P Sahlin, P. B de Reuille, P. H Rubery, Pawel Krupinski, R Gutierrez, R Himmelspach, R. E Peterson, R. E Williamson, R. S Smith, S Douady, S Sakaguchi, W. R Scheible, Y Boutte, Y Cheng   +48 more
core   +6 more sources

RGS14 is a Microtubule-Associated Protein [PDF]

Cell Cycle, 2005
Heterotrimeric G-proteins and their regulators are emerging as important players in modulating microtubule polymerization dynamics and in spindle force generation during cell division in C. elegans, D. melanogaster and mammals. We recently demonstrated that RGS14 is required for completion of the first mitotic division of the mouse embryo, and that it ...
Luke, Martin-McCaffrey, Francis S, Willard, Agnieszka, Pajak, Lina, Dagnino, David P, Siderovski, Sudhir J A, D'Souza   +5 more
openaire   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Non-microtubular localizations of microtubule-associated protein 6 (MAP6).

PLoS ONE, 2014
MAP6 proteins (MAP6s), which include MAP6-N (also called Stable Tubule Only Polypeptide, or STOP) and MAP6d1 (MAP6 domain-containing protein 1, also called STOP-Like protein 21 kD, or SL21), bind to and stabilize microtubules.
Sylvie Gory-Fauré, Vanessa Windscheid, Jacques Brocard, Sylvie Montessuit, Ryouhei Tsutsumi, Eric Denarier, Yuko Fukata, Christophe Bosc, Julie Delaroche, Nora Collomb, Masaki Fukata, Jean-Claude Martinou, Karin Pernet-Gallay, Annie Andrieux   +13 more
doaj   +1 more source

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity

eLife, 2020
The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is
Liu He, Robbelien Kooistra, Ravi Das, Ellen Oudejans, Eric van Leen, Johannes Ziegler, Sybren Portegies, Bart de Haan, Anna van Regteren Altena, Riccardo Stucchi, AF Maarten Altelaar, Stefan Wieser, Michael Krieg, Casper C Hoogenraad, Martin Harterink   +14 more
doaj   +1 more source

Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules

Ecotoxicology and Environmental Safety, 2021
Acute exposure to cadmium (Cd) causes vacuolar degeneration in buffalo rat liver 3 A (BRL 3 A) cells. The present study aimed to determine the relationship between Cd-induced microtubule damage and intracellular vacuolar degeneration.
Junzhao Yuan, Yumeng Zhao, Yuni Bai, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Hui Zou, Jianchun Bian   +8 more
doaj   +1 more source

Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. [PDF]

, 2016
The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
CHISHOLM, Andrew, Tang, Ngang
core   +2 more sources

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source