Results 11 to 20 of about 267,256 (320)
Micron-scale geometrical features of microtubules as regulators of microtubule organization
eLife, 2021 The organization of micron-sized, multi-microtubule arrays from individual microtubules is essential for diverse cellular functions. The microtubule polymer is largely viewed as a passive building block during the organization process.
Nandini Mani +2 more
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Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories
Frontiers in Molecular Neuroscience, 2021 The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and ...
Camille Cuveillier +9 more
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MAP4 as a New Candidate in Cardiovascular Disease
Frontiers in Physiology, 2020 Microtubule and mitochondrial dysfunction have been implicated in the pathogenesis of cardiovascular diseases (CVDs), including cardiac hypertrophy, fibrosis, heart failure, and hypoxic/ischemic related heart dysfunction. Microtubule dynamics instability
Lingfei Li +7 more
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Characterization of human Ccser2 as a protein tracking the plus-ends of microtubules
BMC Research Notes, 2023 Objective Microtubules, which are closely related to cell proliferation, have been the promising therapeutic target of cancer. Therefore, it is necessary to understand the intracellular control mechanisms of microtubules, the whole picture of which is ...
Yuko Shirai +3 more
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Cellular cartography: Towards an atlas of the neuronal microtubule cytoskeleton
Frontiers in Cell and Developmental Biology, 2023 Microtubules, one of the major components of the cytoskeleton, play a crucial role during many aspects of neuronal development and function, such as neuronal polarization and axon outgrowth.
Malina K. Iwanski, Lukas C. Kapitein
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Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
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The Role of Spastin in Axon Biology
Frontiers in Cell and Developmental Biology, 2022 Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mounting body
Ana Catarina Costa +2 more
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Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts [PDF]
, 2001 Oncoprotein 18 (Op18) is a microtubule-destabilizing protein that is negatively regulated by phosphorylation. To evaluate the role of the three Op18 phosphorylation sites in Xenopus (Ser 16, 25, and 39), we added wild-type Op18, a nonphosphorylatable ...
Andersen +67 more
core +4 more sources
Back to the tubule: microtubule dynamics in Parkinson's disease [PDF]
, 2016 Cytoskeletal homeostasis is essential for the development, survival and maintenance of an efficient nervous system. Microtubules are highly dynamic polymers important for neuronal growth, morphology, migration and polarity.
Grannó, S +4 more
core +1 more source
New Insights Into Functions of IQ67-Domain Proteins
Frontiers in Plant Science, 2021 IQ67-domain (IQD) proteins, first identified in Arabidopsis and rice, are plant-specific calmodulin-binding proteins containing highly conserved motifs.
Chunyue Guo +3 more
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