Results 21 to 30 of about 1,205,418 (341)
Micron-scale geometrical features of microtubules as regulators of microtubule organization
The organization of micron-sized, multi-microtubule arrays from individual microtubules is essential for diverse cellular functions. The microtubule polymer is largely viewed as a passive building block during the organization process.
Nandini Mani+2 more
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Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories
The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and ...
Camille Cuveillier+9 more
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Dystrophin is a microtubule-associated protein [PDF]
Cytolinkers are giant proteins that can stabilize cells by linking actin filaments, intermediate filaments, and microtubules (MTs) to transmembrane complexes. Dystrophin is functionally similar to cytolinkers, as it links the multiple components of the cellular cytoskeleton to the transmembrane dystroglycan complex.
Amisha Mehta+6 more
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MAP4 as a New Candidate in Cardiovascular Disease
Microtubule and mitochondrial dysfunction have been implicated in the pathogenesis of cardiovascular diseases (CVDs), including cardiac hypertrophy, fibrosis, heart failure, and hypoxic/ischemic related heart dysfunction. Microtubule dynamics instability
Lingfei Li+7 more
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Cellular cartography: Towards an atlas of the neuronal microtubule cytoskeleton
Microtubules, one of the major components of the cytoskeleton, play a crucial role during many aspects of neuronal development and function, such as neuronal polarization and axon outgrowth.
Malina K. Iwanski, Lukas C. Kapitein
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Characterization of human Ccser2 as a protein tracking the plus-ends of microtubules
Objective Microtubules, which are closely related to cell proliferation, have been the promising therapeutic target of cancer. Therefore, it is necessary to understand the intracellular control mechanisms of microtubules, the whole picture of which is ...
Yuko Shirai+3 more
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RGS14 is a Microtubule-Associated Protein [PDF]
Heterotrimeric G-proteins and their regulators are emerging as important players in modulating microtubule polymerization dynamics and in spindle force generation during cell division in C. elegans, D. melanogaster and mammals. We recently demonstrated that RGS14 is required for completion of the first mitotic division of the mouse embryo, and that it ...
Sudhir J.A. D'Souza+5 more
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Microtubule (MT)–associated protein 7 (MAP7) is a required cofactor for kinesin-1–driven transport of intracellular cargoes. Using cryo–electron microscopy and single–molecule imaging, we investigated how MAP7 binds MTs and facilitates kinesin-1 motility.
Luke S. Ferro+12 more
semanticscholar +1 more source
Microtubule-associated proteins of neurons. [PDF]
Microtubule-associated proteins (MAP) have been identified in cultures of rat sympathetic neurons. In all of the experiments performed here, the cultures consisted of greater than 97% neurons. 26 proteins were identified in these neuronal cultures that (a) remained associated with cytoskeletons prepared with a Triton X-100-containing microtubule ...
J T Kurdyla, M M Black
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The Role of Spastin in Axon Biology
Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mounting body
Ana Catarina Costa+2 more
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