Results 11 to 20 of about 175,942 (250)
Micron-scale geometrical features of microtubules as regulators of microtubule organization
eLife, 2021 The organization of micron-sized, multi-microtubule arrays from individual microtubules is essential for diverse cellular functions. The microtubule polymer is largely viewed as a passive building block during the organization process.
Nandini Mani +2 more
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Beyond Neuronal Microtubule Stabilization: MAP6 and CRMPS, Two Converging Stories
Frontiers in Molecular Neuroscience, 2021 The development and function of the central nervous system rely on the microtubule (MT) and actin cytoskeletons and their respective effectors. Although the structural role of the cytoskeleton has long been acknowledged in neuronal morphology and ...
Camille Cuveillier +9 more
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MAP4 as a New Candidate in Cardiovascular Disease
Frontiers in Physiology, 2020 Microtubule and mitochondrial dysfunction have been implicated in the pathogenesis of cardiovascular diseases (CVDs), including cardiac hypertrophy, fibrosis, heart failure, and hypoxic/ischemic related heart dysfunction. Microtubule dynamics instability
Lingfei Li +7 more
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Cellular cartography: Towards an atlas of the neuronal microtubule cytoskeleton
Frontiers in Cell and Developmental Biology, 2023 Microtubules, one of the major components of the cytoskeleton, play a crucial role during many aspects of neuronal development and function, such as neuronal polarization and axon outgrowth.
Malina K. Iwanski, Lukas C. Kapitein
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RGS14 is a Microtubule-Associated Protein [PDF]
Cell Cycle, 2005 Heterotrimeric G-proteins and their regulators are emerging as important players in modulating microtubule polymerization dynamics and in spindle force generation during cell division in C. elegans, D. melanogaster and mammals. We recently demonstrated that RGS14 is required for completion of the first mitotic division of the mouse embryo, and that it ...
Luke, Martin-McCaffrey +5 more
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Characterization of human Ccser2 as a protein tracking the plus-ends of microtubules
BMC Research Notes, 2023 Objective Microtubules, which are closely related to cell proliferation, have been the promising therapeutic target of cancer. Therefore, it is necessary to understand the intracellular control mechanisms of microtubules, the whole picture of which is ...
Yuko Shirai +3 more
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Dystrophin is a microtubule-associated protein [PDF]
Journal of Cell Biology, 2009 Cytolinkers are giant proteins that can stabilize cells by linking actin filaments, intermediate filaments, and microtubules (MTs) to transmembrane complexes. Dystrophin is functionally similar to cytolinkers, as it links the multiple components of the cellular cytoskeleton to the transmembrane dystroglycan complex.
Prins, Kurt W. +5 more
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Microtubule-Associated Proteins: Structuring the Cytoskeleton [PDF]
Trends in Cell Biology, 2019 Microtubule-associated proteins (MAPs) were initially discovered as proteins that bind to and stabilize microtubules. Today, an ever-growing number of MAPs reveals a more complex picture of these proteins as organizers of the microtubule cytoskeleton that have a large variety of functions.
Bodakuntla, Satish +4 more
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The Role of Spastin in Axon Biology
Frontiers in Cell and Developmental Biology, 2022 Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mounting body
Ana Catarina Costa +2 more
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The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules
eLife, 2022 Cells increase microtubule dynamics to make large rearrangements to their microtubule cytoskeleton during cell division. Changes in microtubule dynamics are essential for the formation and function of the mitotic spindle, and misregulation can lead to ...
Thomas S McAlear, Susanne Bechstedt
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