Distinct Microtubule Organizing Center Mechanisms Combine to Generate Neuron Polarity and Arbor Complexity [PDF]
Frontiers in Cellular Neuroscience, 2020 Dendrite and axon arbor wiring patterns determine the connectivity and computational characteristics of a neuron. The identities of these dendrite and axon arbors are created by differential polarization of their microtubule arrays, and their complexity ...
Oliver R. Wilkes +2 more
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Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites [PDF]
eLife, 2020 A polarized arrangement of neuronal microtubule arrays is the foundation of membrane trafficking and subcellular compartmentalization. Conserved among both invertebrates and vertebrates, axons contain exclusively ‘plus-end-out’ microtubules while ...
Xing Liang +6 more
doaj +5 more sources
Microtubule-organizing center formation at telomeres induces meiotic telomere clustering. [PDF]
J Cell Biol, 2013 Telomere-localized SUN and KASH proteins induce formation of a microtubule-based “telocentrosome” that fosters microtubule motor-dependent telomere clustering.
Yoshida M +12 more
europepmc +6 more sources
The transcription factor Egr3 is a putative component of the microtubule organizing center in mouse oocytes. [PDF]
PLoS ONE, 2014 The early growth response (Egr) family of zinc finger transcription factors consists of 4 members. During an investigation of Egr factor localization in mouse ovaries, we noted that Egr3 exhibits a subcellular localization that overlaps with the meiotic ...
Hyejin Shin +3 more
doaj +4 more sources
The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress [PDF]
eLife, 2022 Cells encountering stressful situations activate the integrated stress response (ISR) pathway to limit protein synthesis and redirect translation to better cope.
Brian Hurwitz +9 more
doaj +5 more sources
AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9 [PDF]
eLife, 2020 The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood. Here, we identify AKAP6 as key component of the nuclear envelope MTOC.
Silvia Vergarajauregui +10 more
doaj +3 more sources
A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome [PDF]
eLife, 2019 The centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules into the mitotic spindle through its pericentriolar material (PCM).
Jérémy Magescas +2 more
doaj +4 more sources
Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond [PDF]
Frontiers in Immunology, 2012 Cytoskeletal polarization is crucial for many aspects of immune function, ranging from neutrophil migration to the sampling of gut flora by intestinal dendritic cells.
Morgan eHuse
doaj +3 more sources
Translation of nervous necrosis virus involves eIF4E but not RPS6 phosphorylation and viral particle assembly in remodeled microtubule-organizing center [PDF]
Virology JournalBackground Nervous necrosis virus (NNV) is a bipartite positive-sense RNA virus that causes piscine viral nervous necrosis disease in larvae and juvenile marine fish.
Vertika Bajpai +11 more
doaj +3 more sources
Elevated Estrogen Receptor-α in VHL-Deficient Condition Induces Microtubule Organizing Center Amplification via Disruption of BRCA1/Rad51 Interaction [PDF]
Neoplasia: An International Journal for Oncology Research, 2014 Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step.
Youn-Sang Jung +3 more
doaj +3 more sources