Anatomy of the fungal microtubule organizing center, the spindle pole body. [PDF]
Curr Opin Struct Biol, 2021 The fungal kingdom is large and diverse, representing extremes of ecology, life cycles and morphology. At a cellular level, the diversity among fungi is particularly apparent at the spindle pole body (SPB). This nuclear envelope embedded structure, which is essential for microtubule nucleation, shows dramatically different morphologies between ...
Jaspersen SL.
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Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly. [PDF]
Mol Biol Cell, 2013 A microtubule nucleator γ-tubulin forms a multiprotein complex (γ-tubulin complex or γ-TuC), which localizes to the microtubule organizing centers (MTOCs). We identify fission yeast Mzt1/MOZART1 as a novel conserved stoichiometric component of the γ-TuC.
Masuda H, Mori R, Yukawa M, Toda T.
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Analysis of Microtubules and Microtubule-Organizing Center at the Immune Synapse. [PDF]
Methods Mol Biol, 2017 The immune synapse (IS) is a specialized structure that enables cell-cell communication between immune cells. As such, it involves direct cell-to-cell contact. It is sustained by cytoskeletal components that allow the intracellular polarization of different organelles and the surface re-organization of signaling and adhesion receptors.
Blas-Rus N +3 more
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Impact of vitrification on the meiotic spindle and components of the microtubule-organizing center in mouse mature oocytes. [PDF]
Biol Reprod, 2013 Tamura AN, Huang TT, Marikawa Y.
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Coordination of Zika Virus Infection and Viroplasm Organization by Microtubules and Microtubule-Organizing Centers [PDF]
Cells, 2021 Zika virus (ZIKV) became a global health concern in 2016 due to its links to congenital microcephaly and other birth defects. Flaviviruses, including ZIKV, reorganize the endoplasmic reticulum (ER) to form a viroplasm, a compartment where virus particles
Rebecca A. Buchwalter +11 more
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Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope [PDF]
eLife, 2021 Non-centrosomal microtubule-organizing centers (MTOCs) are pivotal for the function of multiple cell types, but the processes initiating their formation are unknown. Here, we find that the transcription factor myogenin is required in murine myoblasts for
Robert Becker +7 more
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From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells. [PDF]
Immunol Rev, 2013 Huse M, Le Floc'h A, Liu X.
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Stability and function of a putative microtubule-organizing center in the human parasite <i>Toxoplasma gondii</i>. [PDF]
Mol Biol Cell, 2017 The organization of the microtubule cytoskeleton is dictated by microtubule nucleators or organizing centers. Toxoplasma gondii, an important human parasite, has an array of 22 regularly spaced cortical microtubules stemming from a hypothesized ...
Leung JM +7 more
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Human oocyte microtubule organizing center: a newly identified driver for meiotic spindle assembly in female oocytes. [PDF]
Life Med, 2023 Dong J, Wu T, Sang Q, Wang L.
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Proximity labeling reveals non-centrosomal microtubule-organizing center components required for microtubule growth and localization. [PDF]
Curr Biol, 2021 Sanchez AD +9 more
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