Results 261 to 270 of about 63,482 (321)

Cable Cars to the Nucleus: TM4SF1-Enriched Microdomains Conduct Signaling in Endothelial Cells for Blood Vessel Formation. [PDF]

Int J Mol Sci
Jaminet SC.
europepmc   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Modeling actin-microtubule crosstalk in migrating cells. [PDF]

Biophys J
Nayak P, Dasanna AK, Paul R, Rieger H.
europepmc   +1 more source

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic

Small, EarlyView.
The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho, Katharina Schmidt, Christopher Lambert, Lili Jia, Vignesh Venkatakrishnan, Luisa Mehr, Johan Bylund, Klemens Rottner, Marc Stadler, Theresia E. B. Stradal, Philipp Klahn   +10 more
wiley   +1 more source

In Situ, Real‐Time Imaging of pH Gradients and Solution Flows through Silica Garden Membranes during Tube Growth

Small, EarlyView.
A fluorescent pH probe, added to a saturated metal ion solution, allows for mapping pH during the growth of a silica garden. The probe shows a very intense blue fluorescence at pH around 4 and an intense green fluorescence at pH above 6. The red component of the image allows detection of the formation of particles and tracking solution flows in the ...
Arianna Menichetti, Jeannette Manzi, Dario Mordini, Fermín Otálora, Juan Manuel García‐Ruiz, Marco Montalti   +5 more
wiley   +1 more source

Tubacin alleviate the reproductive toxicity of deoxynivalenol in mouse oocytes and zygotes via strengthening microtubule stability. [PDF]

Cell Commun Signal
Luo H, Chen J, Guo Z, Zhu Y, Wang Y, Wu T, Yin S, Li C, Su Y, Chen Y, Qian Y, Miao C, Feng R.   +12 more
europepmc   +1 more source

A Simple, Ultrastable, and Cost‐Effective Oxygen‐Scavenging System for Long‐Term DNA‐PAINT Imaging

Small, EarlyView.
A simple, enzyme‐free, and cost‐effective oxygen scavenging system enhances DNA‐PAINT super‐resolution microscopy by increasing photostability, minimizing docking strand degradation, and enabling faster, high‐precision localizations. Its long‐term stability supports extended imaging, yielding improved spatial resolution and image quality.
Rebecca T. Perelman, George M. Church, Johannes Stein   +2 more
wiley   +1 more source

Taking the tube to the basal pole of hair cells. [PDF]

Elife
Ghimire SR, Coate TM.
europepmc   +1 more source

Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis

Small, EarlyView.
This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack, Antje Vennemann, Carla Ribalta, Julia Schendel, Oliver Gräb, Rico Ledwith, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit   +9 more
wiley   +1 more source

Primary cilia function as hubs for signal transduction. [PDF]

Cell Biosci
Li B, He YY, Yang ZM.
europepmc   +1 more source