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Microtubule organizing centers and γ-tubulin
Current Opinion in Cell Biology, 1994The polar assembly of cellular microtubules is organized by microtubule organizing centers (MTOCs). Eukaryotic cells across different species, and different cell types within single species, have morphologically diverse MTOCs, which have the common function of organizing microtubule arrays by initiating microtubule assembly and anchoring microtubules ...
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Peroxynitrite deteriorates oocyte quality through disassembly of microtubule organizing centers
Free Radical Biology and Medicine, 2016Previous theoretical studies have suggested that utilization of 3-D imaging to acquire morphologic parameters of meiotic spindles may be useful in infertility related procedures as an assessment of oocyte quality. However, our results show that treatment of oocytes with increasing concentrations of peroxynitrite (ONOO(-)) caused a dramatic alteration ...
Sana N, Khan +6 more
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Fungal microtubule organizing centers are evolutionarily unstable structures
Fungal Genetics and BiologyFor most Eukaryotic species the requirements of cilia formation dictate the structure of microtubule organizing centers (MTOCs). In this study we find that loss of cilia corresponds to loss of evolutionary stability for fungal MTOCs. We used iterative search algorithms to identify proteins homologous to those found in Saccharomyces cerevisiae, and ...
Adam, Grazzini, Ann M, Cavanaugh
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The centrosome in vertebrates: more than a microtubule-organizing center
Trends in Cell Biology, 2001The somatic cells of all higher animals contain a single minute organelle called the centrosome. For years, the functions of the centrosome were thought to revolve around its ability to nucleate and organize the various microtubule arrays seen in interphase and mitosis. But the centrosome is more than just a microtubule-organizing center.
C L, Rieder, S, Faruki, A, Khodjakov
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Microtubule-Organizing Centers and Nucleating Sites in Land Plants
1998Microtubule-organizing centers (MTOCs) are morphologically diverse cellular sites involved in the nucleation and organization of microtubules (MTs). These structures are synonymous with the centrosome in mammalian cells. In most land plant cells, however, no such structures are observed and some have argued that plant cells may not have MTOCs.
K C, Vaughn, J D, Harper
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Microtubule-Organizing Centers of the Mitotic Spindle
1977Discussions of the regulation of microtubule assembly generally have had a dual aspect. Firstly, they have been in terms of the extent of assembly; that is, in terms of whether and to what degree assembly is favoured or not. Secondly, and of equal significance to the amount of microtubules, discussions have focused on their spatial distribution within ...
G. G. Borisy, R. R. Gould, H. Ponstingl
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γ-Tubulin complexes and their interaction with microtubule-organizing centers
Current Opinion in Structural Biology, 1999Gamma-tubulin is as ubiquitous in eukaryotes as alpha- and beta-tubulin. Rather than forming part of the microtubule wall, however, gamma-tubulin is involved in microtubule nucleation. Although gamma-tubulin concentrates at microtubule-organizing centers, it also exists in a cytoplasmic complex whose size and complexity depends on the organism and cell
C, Wiese, Y, Zheng
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Histochemistry and Cell Biology, 2021
Koyo Ide, Mika Muko, Kensuke Hayashi
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Koyo Ide, Mika Muko, Kensuke Hayashi
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The herbicide sindone B disrupts spindle microtubule organizing centers
Pesticide Biochemistry and Physiology, 1992Abstract Sindone B is classified as a “mitotic disrupter herbicide”, but little information is published on the physiological effects of this structurally unique compound. Onion root tips treated with various concentrations of sindone B were examined by light microscopy following Feulgen staining, immunofluorescence of tubulin, and electron ...
Larry P. Lehnen, Kevin C. Vaughn
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Cytoplasmic transfer of microtubule organizing centers in mouse tissue culture cells
Cell, 1978Abstract A chloramphenicol-resistant, aminopterin-sensitive cell line (AMT) derived from a mouse mammary tumor MT-29240 was enucleated, and the cytoplasts were fused with nucleated chloramphenicol-sensitive, HAT-resistant SV40 3T3 mouse cells. The resulting cytoplasmic hybrids (cybrids) were selected for their resistance to chloramphenicol and the ...
Shay, J W, Peters, T T, Fuseler, J W
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