Results 201 to 210 of about 199,967 (323)

Intrinsically Disordered Peptide Nanofibers from A Structured Motif within Proteins

open access: yesAngewandte Chemie International Edition, Accepted Article.
Intrinsically disordered regions (IDRs) are ubiquitous in pro‐teins, orchestrating complex cellular signaling through high‐er‐order protein assemblies. However, the properties and functions of intrinsically disordered peptide (IDP) assemblies are largely underexplored. This work unveiled a facile strategy for engineering IDP assemblies.
Yuchen Qiao   +7 more
wiley   +1 more source

A cytotoxic survey on 2‐amino‐1H‐imidazol based synthetic marine sponge alkaloid analogues

open access: yesDrug Development Research, Volume 83, Issue 8, Page 1906-1922, December 2022., 2022
Abstract Here, we describe the synthesis and biologic activity evaluation of 20 novel synthetic marine sponge alkaloid analogues with 2‐amino‐1H‐imidazol (2‐AI) core. Cytotoxicity was tested on murine 4T1 breast cancer, A549 human lung cancer, and HL‐60 human myeloid leukemia cells by the resazurin assay.
Nikolett Gémes   +10 more
wiley   +1 more source

Convergent Assembly of Homo‐ and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol‐Ene Chemistry

open access: yesAngewandte Chemie International Edition, EarlyView.
Generating functionalized ubiquitin building blocks via expression in E. coli paves the way to different di‐, tri‐, and tetra‐ubiquitin chains. Light‐induced thiol‐ene click reactions, combined with a masking and protection strategy, are harnessed to establish controlled ubiquitin chain assembly and to allow the semisynthesis of site‐selectively ...
Moritz Urschbach   +6 more
wiley   +1 more source

Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C. [PDF]

open access: yesCancer Cell Int
Sulimenko V   +6 more
europepmc   +1 more source

The Chemical Characterization of Calf Brain Microtubule Protein Subunits

open access: hybrid, 1973
James Lee   +2 more
openalex   +1 more source

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