Results 201 to 210 of about 406,325 (331)

Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends [PDF]

, 2017
Anil Kumar, Cristina Manatschal, Ankit Rai, Ilya Grigoriev, Miriam Steiner Degen, Rolf Jaussi, Ines Kretzschmar, A.E. Prota, Rudolf Volkmer, Richard A. Kammerer, Anna Akhmanova, Michel O. Steinmetz   +11 more
openalex   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Identification of locally activated spindle-associated proteins in oocytes uncovers a phosphatase-driven mechanism. [PDF]

J Cell Sci
Wan X, Pavlova G, Cullen CF, Dasuzhau I, Ciszek A, Ohkura H.   +5 more
europepmc   +1 more source

Prickle/spiny-legs isoforms control the polarity of the apical microtubule network in planar cell polarity

, 2014
Jessica Olofsson, Katherine A. Sharp, Maja Matis, Bomsoo Cho, Jeffrey D. Axelrod   +4 more
openalex   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

The luminal ring protein C2CD3 acts as a radial in-to-out organizer of the distal centriole and appendages. [PDF]

PLoS Biol
Bertiaux E, Louvel V, McCafferty CL, van den Hoek H, Batman U, Mukherjee S, Bournonville L, Mercey O, Méan I, Righetto RD, Müller A, Van der Stappen P, Buss G, Daraspe J, Genoud C, Stearns T, Engel BD, Hamel V, Guichard P.   +18 more
europepmc   +1 more source

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells

, 2019
Don‐Marc Franchini, Olivia Lanvin, Marie Tosolini, Emilie Patras de Campaigno, Anne Cammas, Sarah Péricart, Clara‐Maria Scarlata, Morgane Le Bras, Cédric Rossi, Lætitia Ligat, Frédéric Pont, Paola B. Arimondo, Camille Laurent, Maha Ayyoub, Fabien Despas, Maryse Lapeyre‐Mestre, Stefania Millevoi, Jean‐Jacques Fournié   +17 more
openalex   +1 more source

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Advanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang, Yanling He, Pin Yang, Hengchang Zhang, Yueyang Tong, Lingling Jiang, Zehan Li, Meichen Yan, Xiaoheng Li, Qinghu Yang, Jing Yang, Zengqiang Yuan, Jiyan Zhang, Jinbo Cheng   +13 more
wiley   +1 more source

Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2. [PDF]

Elife
Chen S, Basiashvili T, Hutchings J, Sanz Murillo M, Villagran Suarez A, Xiong E, Alegrio Louro J, Leschziner AE, Villa E.   +8 more
europepmc   +1 more source

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source