Results 181 to 190 of about 289,777 (310)

<i>Arabidopsis</i> TPXL Proteins Mediate a Selective Aurora Kinase-Microtubule Association During Cell Division. [PDF]

Int J Mol Sci
Cao S, Chen Y, Weng Z, Ren H, Du P.
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier function. [PDF]

Angiogenesis
Bougaran P, Buglak DB, Neal A, Rathod M, Gore M, Hockenberry MA, Amin AA, Tanke N, Oatley M, Legant WR, Liu Z, Bear JE, Polacheck WJ, Bautch VL.   +13 more
europepmc   +1 more source

Microtubule MAPping

Cell, 1990
openaire   +2 more sources

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Beyond STMN1: stathmin-family control of microtubule dynamics and paclitaxel resistance in cancer. [PDF]

Front Oncol
Li H, Shi L, Wang Q, Han W.
europepmc   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases. [PDF]

Elife
Gangadharan B, Kober DL, Rice LM.
europepmc   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Declining centromere strength compromises meiotic chromosome segregation in aging oocytes. [PDF]

J Cell Biol
Lemonnier T, Dumont M, Leem J, Khan A, Yazdkhasti H, Zimyanin V, Khutsaidze A, Redemann S, Fachinetti D, Mogessie B.   +9 more
europepmc   +1 more source