Results 111 to 120 of about 131,190 (318)

HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2

Nature Communications
In vertebrate spindles, most microtubules are formed via branching microtubule nucleation, whereby microtubules nucleate along the side of pre-existing microtubules.
Venecia Alexandria Valdez, Meisheng Ma, Bernardo Gouveia, Rui Zhang, Sabine Petry   +4 more
doaj   +1 more source

Acetylated alpha-tubulin in Trypanosoma cruzi: immunocytochemical localization

Memorias do Instituto Oswaldo Cruz, 1993
We have used monoclonal antibodies specific for acetylated and non-acetylated alpha-tubulin to localize microtubules containing acetylated alpha-tubulin in all developmental forms of the life cycle of Trypanosoma cruzi.
Thais Souto-Padron, Narcisa L. Cunha e Silva, Wanderley de Souza   +2 more
doaj   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielman, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Efficient imaging and computer vision detection of two cell shapes in young cotton fibers

Applications in Plant Sciences, Volume 10, Issue 6, November-December 2022., 2022
Abstract Premise The shape of young cotton (Gossypium) fibers varies within and between commercial cotton species, as revealed by previous detailed analyses of one cultivar of G. hirsutum and one of G. barbadense. Both narrow and wide fibers exist in G. hirsutum cv.
Benjamin P. Graham, Jeremy Park, Grant T. Billings, Amanda M. Hulse‐Kemp, Candace H. Haigler, Edgar Lobaton   +5 more
wiley   +1 more source

Fission yeast mtr1p regulates interphase microtubule cortical dwell-time

Biology Open, 2014
The microtubule cytoskeleton plays important roles in cell polarity, motility and division. Microtubules inherently undergo dynamic instability, stochastically switching between phases of growth and shrinkage.
Frédérique Carlier-Grynkorn, Liang Ji, Vincent Fraisier, Berangère Lombard, Florent Dingli, Damarys Loew, Anne Paoletti, Xavier Ronot, Phong T. Tran   +8 more
doaj   +1 more source

Modified heptapeptide from tau binds both tubulin and microtubules

Thoracic Cancer, 2020
Background Microtubules are the major cytoskeletal component in eukaryotes which are essential for a large spectrum of cellular activities. Monitoring the behavior of microtubules is helpful for a better understanding of the regulatory mechanism ...
Jingrui Li, Yuyang Li, Min Liu, Songbo Xie   +3 more
doaj   +1 more source

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Unwrapping the Ciliary Coat: High‐Resolution Structure and Function of the Ciliary Glycocalyx

Advanced Science, EarlyView.
The ciliary membrane is decorated in glycosylated proteins that define the interaction of the cilium with its environment. The main component of the ciliary coat of the green alga Chlamydomonas reinhardtii, FMG1, is characterized by cryo‐electron microscopy, proteomics, and live cell microscopy with flow‐based adhesion assays.
Lara M. Hoepfner, Adrian P. Nievergelt, Fabrizio Matrino, Martin Scholz, Helen E. Foster, Jonathan Rodenfels, Alexander von Appen, Michael Hippler, Gaia Pigino   +8 more
wiley   +1 more source