Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance
Advanced Science, EarlyView.Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao +5 more
wiley +1 more source
Involvement of microtubule and microfilament system in the GnRH‐induced release of gonadotropins by rat anterior pituitary cells in culture [PDF]
, 1979 Ashok Khar, Maciej Radek, M Jutisz
openalex +1 more source
Advanced Science, EarlyView.ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang +6 more
wiley +1 more source
Competitive inhibition of colchicine binding to tubulin by microtubule-associated proteins.
, 1979 J. Núñez +3 more
openalex +2 more sources
The growth speed of microtubules with XMAP215-coated beads coupled to their ends is increased by tensile force [PDF]
, 2013 Anastasiya Trushko +2 more
openalex +1 more source
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
Advanced Science, EarlyView.SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis [PDF]
, 2008 Thomas M. Durcan +6 more
openalex +1 more source
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
Cytoskeletal Regulation: Coordinating Actin and Microtubule Dynamics in Membrane Trafficking [PDF]
, 2008 Andrea Disanza, Giorgio Scita
openalex +1 more source
Microtubules & Microtubule-associated Proteins [PDF]
Biophysical Journal, 2008 openaire +1 more source