Results 281 to 290 of about 249,538 (351)

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

The KASH protein UNC-83 differentially regulates kinesin-1 activity to control developmental stage-specific nuclear migration. [PDF]

Curr Biol
Gümüşderelioğlu S, Sahabandu N, Elnatan D, Gregory EF, Chiba K, Niwa S, Luxton GWG, McKenney RJ, Starr DA.   +8 more
europepmc   +1 more source

Evidence for firm linkages between microtubules and membrane-bounded vesicles.

, 1975
Richard D. Allen
openalex   +1 more source

The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts

Cytoskeleton, EarlyView.
ABSTRACT A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types.
Guadalupe E. Pena, Xiao Zhou, Lauren Slevin, Christopher Brownlee, Rebecca Heald   +4 more
wiley   +1 more source

Form and function in biological filaments: a physicist's review. [PDF]

Philos Trans A Math Phys Eng Sci
Cammann J, Laeverenz-Schlogelhofer H, Wan KY, Mazza MG.   +3 more
europepmc   +1 more source

Mechanical Coupling With the Nuclear Envelope Shapes the Schizosaccharomyces pombe Mitotic Spindle

Cytoskeleton, EarlyView.
ABSTRACT The fission yeast Schizosaccharomyces pombe divides via closed mitosis, meaning that spindle elongation and chromosome segregation transpire entirely within the closed nuclear envelope. Both the spindle and nuclear envelope must undergo shape changes and exert varying forces on each other during this process.
Marcus A. Begley, Taylor Mahoney, Christian Pagán Medina, Parsa Zareiesfandabadi, Matthew B. Rapp, Mastawal Tirfe, Sharonda J. LeBlanc, Meredith D. Betterton, Mary Williard Elting   +8 more
wiley   +1 more source

The microtubule-severing enzyme spastin regulates spindle dynamics to promote chromosome segregation in Trypanosoma brucei. [PDF]

Commun Biol
Souza Onofre T, Zhou Q, Li Z.
europepmc   +1 more source

Dissecting the Structural Organization, Recruitment and Activation Mechanisms of Centrosomal γ‐TuRCs

Cytoskeleton, EarlyView.
ABSTRACT Visualizing human centrosomes using cryo‐electron tomography revealed the native structure and molecular organization of γ‐tubulin ring complexes (γ‐TuRCs). γ‐TuRCs localized to two distinct centrosomal pools, one in the pericentriolar material (PCM) and another in the centriole lumen, which is released during mitosis.
Florian W. Hofer, Martin Würtz, Qi Gao, Bram J. A. Vermeulen, Elmar Schiebel, Stefan Pfeffer   +5 more
wiley   +1 more source

Microtubule MAPping

Cell, 1990
openaire   +2 more sources

Reversible arginine methylation of PI3KC2α controls mitotic spindle dynamics. [PDF]

Cell Commun Signal
Cho Y, Hwang JW, Bedford MT, Na DH, Song DG, Kim SN, Kim YK.   +6 more
europepmc   +1 more source