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Microtubules in cell migration.

Annual Review of Cell and Developmental Biology, 2013
Migration is a polarized cellular process that opposes a protrusive front edge to a retracting trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell protrusion, adhesion, contraction, and retraction.
S. Étienne-Manneville
semanticscholar   +1 more source

Microtubules and spermatogenesis

Seminars in Cell & Developmental Biology, 2014
Microtubules are dynamic polymers of tubulin subunits that underpin many essential cellular processes, such as cell division and migration. Spermatogenesis is the process by which spermatogenic stem cells undergo mitotic and meiotic division and differentiation to produce streamlined spermatozoa capable of motility and fertilization.
O'Donnell, L., O'Bryan, M.
openaire   +4 more sources

Mechanism of action of antitumor drugs that interact with microtubules and tubulin.

, 2012
Microtubules, major structural components in cells, are the target of a large and diverse group of natural product anticancer drugs. Given the success of this class of drugs in cancer treatment, it can be argued that microtubules represent the single ...
J. Ma
semanticscholar   +1 more source

Microtubule dynamics

Current Opinion in Cell Biology, 1992
Although compelling evidence has been obtained for heterogeneity in the structure of subunits in microtubules, it has not been possible to prove that this results from the presence of tubulin-GDP and tubulin-GTP in polymers. There are reasons to exclude the existence of even a monolayer of tubulin-GTP subunits at microtubule ends.
openaire   +2 more sources

Microtubule-dependent microtubule nucleation in plant cells

Journal of Plant Research, 2006
Regulation of microtubule nucleation sites is an essential step in microtubule organization. Cortical microtubule arrays in green plant cells at inter-phase are organized in a distinct manner--the array is formed in the absence of previously recognized organelles for microtubule nucleation, for example the centrosome and spindle pole body. Microtubules
Takashi Murata   +3 more
openaire   +3 more sources

Microtubules and Maps

2005
Microtubules are very dynamic polymers whose assembly and disassembly is determined by whether their heterodimeric tubulin subunits are in a straight or curved conformation. Curvature is introduced by bending at the interfaces between monomers. Assembly and disassembly are primarily controlled by the hydrolysis of guanosine triphosphate (GTP) in a site
Daniel Schlieper, Linda A. Amos
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Interaction of griseofulvin with microtubules, microtubule protein and tubulin

Journal of Molecular Biology, 1977
The interaction of the anti-mitotic drug griseofulvin with microtubule protein, microtubules and tubulin was studied by light scattering analysis and electron microscopy in two different systems: (1) microtubule assembly in the absence of glycerol, which depends on the presence of microtubule-associated proteins and (2) microtubule assembly in the ...
Jürgen Wehland   +2 more
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Microtubules in the Lens

Archives of Ophthalmology, 1968
Microtubules were regularly demonstrated in lens cells. They were especially abundant in the cortex at the equator where the movement of lens cells is most active. The microtubules may serve to maintain the shape and rigidity of the lens cell at the portion of constant movement.
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Focusing-in on microtubules

Current Opinion in Structural Biology, 2000
A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins ...
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Microtubule nucleation

Current Opinion in Cell Biology, 2003
Microtubule nucleation is the process in which several tubulin molecules interact to form a microtubule seed. Microtubule nucleation occurs spontaneously in purified tubulin solutions, and molecular intermediates between tubulin dimers and microtubules have been identified.
Didier, Job   +2 more
openaire   +2 more sources

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