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Isolation of Microtubules and Microtubule-Associated Proteins
2016Microtubules are essential cellular structures in plant cells. They are polymerized from tubulin dimers and are regulated by microtubule-associated proteins (MAPs). Here, we describe a protocol for purifying tubulin dimers and MAPs from plant cells.
Seiji Sonobe, Takahiro Hamada
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Microtubules and Microtubule Motors: Mechanisms of Regulation
1996Microtubule-based motility is precisely regulated, and the targets of regulation may be the motor proteins, the microtubules, or both components of this intricately controlled system. Regulation of microtubule behavior can be mediated by cell cycle-dependent changes in centrosomal microtubule nucleating ability and by cell-specific, microtubule ...
Catherine D. Thaler, Leah T. Haimo
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Journal of Biomechanics, 2010
Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and cellular processes. For instance, microtubules for the support structures for extended morphologies, such as axons and cilia. Further, microtubules act as tension rods to pull apart chromosomes during cellular division. Unlike other cytoskeletal filaments (e.g.
Matthew Mirigian +3 more
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Microtubules are rigid cytoskeletal filaments, and their mechanics affect cell morphology and cellular processes. For instance, microtubules for the support structures for extended morphologies, such as axons and cilia. Further, microtubules act as tension rods to pull apart chromosomes during cellular division. Unlike other cytoskeletal filaments (e.g.
Matthew Mirigian +3 more
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Microtubules and spermatogenesis
Seminars in Cell & Developmental Biology, 2014Microtubules are dynamic polymers of tubulin subunits that underpin many essential cellular processes, such as cell division and migration. Spermatogenesis is the process by which spermatogenic stem cells undergo mitotic and meiotic division and differentiation to produce streamlined spermatozoa capable of motility and fertilization.
O'Donnell, L., O'Bryan, M.
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Current Opinion in Cell Biology, 1992
Although compelling evidence has been obtained for heterogeneity in the structure of subunits in microtubules, it has not been possible to prove that this results from the presence of tubulin-GDP and tubulin-GTP in polymers. There are reasons to exclude the existence of even a monolayer of tubulin-GTP subunits at microtubule ends.
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Although compelling evidence has been obtained for heterogeneity in the structure of subunits in microtubules, it has not been possible to prove that this results from the presence of tubulin-GDP and tubulin-GTP in polymers. There are reasons to exclude the existence of even a monolayer of tubulin-GTP subunits at microtubule ends.
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Microtubule-dependent microtubule nucleation in plant cells
Journal of Plant Research, 2006Regulation of microtubule nucleation sites is an essential step in microtubule organization. Cortical microtubule arrays in green plant cells at inter-phase are organized in a distinct manner--the array is formed in the absence of previously recognized organelles for microtubule nucleation, for example the centrosome and spindle pole body. Microtubules
Takashi Murata +3 more
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Archives of Ophthalmology, 1968
Microtubules were regularly demonstrated in lens cells. They were especially abundant in the cortex at the equator where the movement of lens cells is most active. The microtubules may serve to maintain the shape and rigidity of the lens cell at the portion of constant movement.
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Microtubules were regularly demonstrated in lens cells. They were especially abundant in the cortex at the equator where the movement of lens cells is most active. The microtubules may serve to maintain the shape and rigidity of the lens cell at the portion of constant movement.
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2005
Microtubules are very dynamic polymers whose assembly and disassembly is determined by whether their heterodimeric tubulin subunits are in a straight or curved conformation. Curvature is introduced by bending at the interfaces between monomers. Assembly and disassembly are primarily controlled by the hydrolysis of guanosine triphosphate (GTP) in a site
Daniel Schlieper, Linda A. Amos
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Microtubules are very dynamic polymers whose assembly and disassembly is determined by whether their heterodimeric tubulin subunits are in a straight or curved conformation. Curvature is introduced by bending at the interfaces between monomers. Assembly and disassembly are primarily controlled by the hydrolysis of guanosine triphosphate (GTP) in a site
Daniel Schlieper, Linda A. Amos
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Interaction of griseofulvin with microtubules, microtubule protein and tubulin
Journal of Molecular Biology, 1977The interaction of the anti-mitotic drug griseofulvin with microtubule protein, microtubules and tubulin was studied by light scattering analysis and electron microscopy in two different systems: (1) microtubule assembly in the absence of glycerol, which depends on the presence of microtubule-associated proteins and (2) microtubule assembly in the ...
Jürgen Wehland +2 more
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Current Opinion in Structural Biology, 2000
A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins ...
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A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins ...
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