Results 61 to 70 of about 331,243 (309)

Inhibition of Rho kinase decreases hydraulic and protein microvascular permeability in cat skeletal muscle

, 2003
Rho-associated kinases are involved in regulation of actin–myosin contractility and the organization of the actin cytoskeleton in both endothelial and smooth muscle cells.
Bentzer, Peter,, Lundblad, Cornelia,, Lund University., Grände, Per-Olof,   +3 more
core   +1 more source

Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism [PDF]

, 2005
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain barrier and transmigrate into the central nervous ...
S. Jayasekera, N. A. Khan, M. Stins, K. S. Kim, Alsam, S., Stins, M., Khan, Naveed Ahmed, Sissons, J., J. Sissons, Kim, K.S., Jayasekera, S., S. Alsam   +11 more
core   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

The C Allele of rs2073618 and rs3134069 of the Osteoprotegerin Gene Is Associated with Diabetic Retinopathy in Slovenian Patients with Type 2 Diabetes

Diabetology
Background: Osteoprotegerin (OPG) is best known for regulating bone remodeling, vascular calcification, apoptosis, and immune responses. Recent studies also suggest that OPG may play an important role in diabetic microvascular complications such as ...
Stella Stare, Ema Šuligoj, Melina Bešić, Jernej Letonja, Mojca Globočnik Petrovič, Ines Cilenšek, Daniel Petrovič   +6 more
doaj   +1 more source

Relationship between Sialic acid and metabolic variables in Indian type 2 diabetic patients

Lipids in Health and Disease, 2005
Background Plasma sialic acid is a marker of the acute phase response. Objective is to study the relationship between sialic acid relationship with metabolic variables in Indian type 2 diabetes with and without microvascular complications.
Nayak B Shivananda, Bhaktha Geetha
doaj   +1 more source

Degree of adiposity and obesity severity is associated with cutaneous microvascular dysfunction in type 2 diabetes

, 2021
Backgrounds and aims: Obesity and diabetes independently contribute to cutaneous microvascular dysfunction via pathological processes that are not fully understood.
Baker, Michael K., Johnson, Nathan A., Sabag, Angelo (R19940), Way, Kimberley L., Gerofi, James, Caterson, Ian D., Sultana, Rachelle N., Twigg, Stephen M., Chuter, Vivienne H., Lanting, Sean M. (R20950)   +9 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Study of neutrophil-lymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes

Indian Journal of Endocrinology and Metabolism, 2017
Introduction: Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion.
Sagar Ashokrao Khandare, Sachin Chittawar, Nitin Nahar, T N Dubey, Zahraan Qureshi   +4 more
doaj   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Diabetic Retinopathy May Indicate an Increased Risk of Cardiovascular Disease in Patients With Type 1 Diabetes—A Nested Case-Control Study in Brazil

Frontiers in Endocrinology, 2019
Objective: Cardiovascular disease, the leading cause of death worldwide, and diabetic retinopathy, the main cause of blindness in economically active populations, share clinical risk factors, and pathophysiological features.
Laura Gomes Nunes Melo, Paulo Henrique Morales, Karla Rezende Guerra Drummond, Karla Rezende Guerra Drummond, Deborah Conte Santos, Marcela Haas Pizarro, Bianca Senger Vasconcelos Barros, Tessa Cerqueria Lemos Mattos, André Araújo Pinheiro, Felipe Mallmann, Franz Schubert Lopes Leal, Luiza Harcar Muniz, Fernando Korn Malerbi, Marilia Brito Gomes   +13 more
doaj   +1 more source