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Cytotoxicity of cytokines in cerebral microvascular endothelial cell
Brain Research, 2003Several studies reported that the levels of proinflammatory cytokines such as TNF-alpha, IL-1beta, IL-6, and IL-8 are elevated in the cerebrospinal fluid (CSF) of patients after subarachnoid hemorrhage (SAH). Cytokines in CSF may contribute to the development of vasospasm and cerebral ischemia.
Hitoshi, Kimura +3 more
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Microvascular Endothelial Cell Shape and Size in Situ
Microvascular Research, 1993To estimate total cleft length per unit surface area, previous studies assumed that endothelial cell clefts were oriented randomly with respect to the axis of the microvessel (Bundgaard and Frøkjaer-Jensen, Microvasc. Res. 23, 1-30, 1982). In the present study, silver precipitation along the intercellular clefts of capillary endothelium ("silver lines")
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Microvascular endothelial cell heterogeneity: Interactions with leukocytes and tumor cells
Cancer and Metastasis Reviews, 1990Endothelium constitutes a highly specialized organ that lines the vascular system and lymphatic channels. This organ is a complex network of arteries, veins, and microvessels that differ in size, structure, and function. The unique and strategic location imposes functional demands on the endothelium that are far greater than just being a passive ...
P N, Belloni, R J, Tressler
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Bevacizumab and ranibizumab on microvascular endothelial cells: A comparative study
Journal of Cellular Biochemistry, 2009AbstractGiven its broad effects in endothelium, vascular endothelial growth factor (VEGF) represents the primary rate‐limiting step of angiogenesis. Therefore, VEGF targeting therapies were soon developed. Bevacizumab and ranibizumab are two of these therapeutic agents already in clinical use.
Raquel, Costa +6 more
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The response of human dermal microvascular endothelial cells to hypoxia
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1994Dermal microvascular endothelial cells (DMEC) exposed to hypoxic conditions show a rapid induction of several proteins that do not increase in other cell types placed in a similar environment. These DMEC proteins differ from the well-characterized stress proteins that have been observed in a wide variety of cultured cell types.
J, Mansbridge +6 more
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Microvascular Endothelial Cells from Heart
1990Endothelial cells from macrovascular and microvascular vessels differ in many of their physiological properties [20, 21, 36, 55, 72]. For a detailed analysis of the metabolism and the physiological function of the microvascular endothelium, cultures of microvascular cells are required.
H. M. Piper +4 more
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Microvascular Endothelial Cells from Brain
1990In addition to providing a nonthrombogenic surface, synthesizing factor VIII, and participating in vascular tone regulation, most endothelial cells of the vasculature of the brain participate in the blood-brain barrier. The bloodbrain barrier severely restricts the entry of macromolecules into nervous tissue and provides a selective permeability ...
P. D. Bowman +3 more
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The heteromorphology of cultured microvascular endothelial cells.
Arzneimittel-Forschung, 1994Endothelial cells alter morphology easily when culture conditions change. One has omitted to test carefully whether this heteromorphology represents constitutional differences which are maintained in culture. Cells were isolated from the microvascular tree of the bovine corpus luteum by mechanical disintegration, i.e.
K, Spanel-Borowski, A, Fenyves
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Microvascular Endothelial Cells from the Lungs
1990The overwhelming majority of all the endothelial cells in the body are found in the pulmonary microcirculation. However, despite early recognition that many of the most important functions attributable to the pulmonary vasculature occur at the level of the small vessels of the lungs [1, 2], relatively few in vitro studies have used endothelial cells ...
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