Results 31 to 40 of about 204,813 (306)

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Journal of Neuroinflammation, 2018
Background Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory product. Protease-activated receptor 2
Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian   +5 more
doaj   +1 more source

Plasmodium falciparum Parasite Lines Expressing DC8 and Group A PfEMP1 Bind to Brain, Intestinal, and Kidney Endothelial Cells

Frontiers in Cellular and Infection Microbiology, 2022
Cytoadhesion of Plasmodium falciparum-infected red blood cells is a virulence determinant associated with microvascular obstruction and organ complications.
Luana S. Ortolan, Marion Avril, Jun Xue, Karl B. Seydel, Karl B. Seydel, Ying Zheng, Joseph D. Smith, Joseph D. Smith   +7 more
doaj   +1 more source

Uptake and cytotoxicity of citrate-coated gold nanospheres : comparative studies on human endothelial and epithelial cells [PDF]

, 2012
The use of gold nanoparticles (AuNPs) for diagnostic applications and for drug and gene-delivery is currently under intensive investigation. For such applications, biocompatibility and the absence of cytotoxicity of AuNPs is essential. Although generally
Couraud, Pierre-Olivier, Freese, Christian, Gibson, Matthew I., Kirkpatrick, C. J. (C. James), Romero, Ignacio A., Uboldi, Chiara, Unger, Ronald E., Weksler, Babette B.   +7 more
core   +7 more sources

Verocytotoxin-Induced Apoptosis of Human Microvascular Endothelial Cells [PDF]

Journal of the American Society of Nephrology, 2001
Abstract. The pathogenesis of the epidemic form of hemolytic uremic syndrome is characterized by endothelial cell damage. In this study, the role of apoptosis in verocytotoxin (VT)-mediated endothelial cell death in human glomerular microvascular endothelial cells (GMVEC), human umbilical vein endothelial cells, and foreskin ...
Pijpers, A.H.J.M., Setten, P.A. van, Heuvel, L.P.W.J. van den, Assmann, K.J.M., Dijkman, H.B.P.M., Pennings, A.H.M., Monnens, L.A.H., Hinsbergh, V.W.H. van   +7 more
openaire   +4 more sources

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels. [PDF]

, 2016
BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs.
Brooks, G, Fan, LM, Ghazaly, MM, Howlin, B, Krönke, M, Li, J-M, Meijles, DN   +6 more
core   +1 more source

Anti-endothelial cell antibodies in pathogenesis of vasculitis

Frontiers in Immunology
Vasculitis is a group of syndromes characterized by inflammation, presence of autoantibodies and endothelial cells (ECs) damage, which lead to stenosis or occlusion of the vascular lumen. Anti-endothelial cell antibodies (AECAs) are a heterogeneous group
Tian Zhang, Tian Zhang, Tian Zhang, Liqun Li, Shengshi Huang, Shengshi Huang, Shengshi Huang, Maria N. Starodubtseva, Maria N. Starodubtseva, Ju Liu, Ju Liu, Ju Liu   +11 more
doaj   +1 more source

Human Liver Endothelial Cells, But Not Macrovascular or Microvascular Endothelial Cells, Engraft in the Mouse Liver

Cell Transplantation, 2013
Liver cell transplantation has had limited clinical success so far, partly due to poor engraftment of hepatocytes. Instead of hepatocytes. other cell types, such as endothelial cells, could be used in ex vivo liver gene therapy.
Ebtisam El Filali, Johan K. Hiralall, Henk A. Van Veen, Donna B. Stolz, Jurgen Seppen   +4 more
doaj   +1 more source

Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]

, 2018
Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J., Petrie, John R., Touyz, Rhian M.   +2 more
core   +1 more source

Microvascular Endothelial Cell Culture.

Journal of Investigative Dermatology, 1989
Microvascular endothelial cells play a central role in inflammation, tumor metastasis, and wound healing. Methods to study these processes in vitro using cells isolated from adult skin, from the inner and the outer segments of the neontal foreskin, and from experimental animals are reviewed.
openaire   +2 more sources

Isolation of Primary Murine Brain Microvascular Endothelial Cells [PDF]

Journal of Visualized Experiments, 2014
The blood-brain-barrier is ultrastructurally assembled by a monolayer of brain microvascular endothelial cells (BMEC) interconnected by a junctional complex of tight and adherens junctions. Together with other cell-types such as astrocytes or pericytes, they form the neurovascular unit (NVU), which specifically regulates the interchange of fluids ...
Ruck, Tobias, Bittner, Stefan, Epping, Lisa, Herrmann, Alexander M., Meuth, Sven G.   +4 more
openaire   +2 more sources