Results 11 to 20 of about 123,827 (263)

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Nature Communications, 2023
Vascular mechanisms of Alzheimer’s disease (AD) may constitute a therapeutically addressable biological pathway underlying dementia. We previously demonstrated that soluble pathogenic forms of tau (tau oligomers) accumulate in brain microvasculature of ...
Stacy A. Hussong, Andy Q. Banh, Candice E. Van Skike, Angela O. Dorigatti, Stephen F. Hernandez, Matthew J. Hart, Beatriz Ferran, Haneen Makhlouf, Maria Gaczynska, Pawel A. Osmulski, Salome A. McAllen, Kelly T. Dineley, Zoltan Ungvari, Viviana I. Perez, Rakez Kayed, Veronica Galvan   +15 more
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Immunomagnetic Isolation and Enrichment of Microvascular Endothelial Cells from Human Adipose Tissue

Bio-Protocol, 2022
Human adipose tissue-resident microvascular endothelial cells are not only garnering attention for their emergent role in the pathogenesis of obesity-related metabolic disorders, but are also of considerable interest for vascular tissue engineering due ...
Jeremy Antonyshyn, Vienna Mazzoli, Meghan McFadden, Anthony Gramolini, Stefan Hofer, Craig Simmons, J. Paul Santerre   +6 more
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Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro

Pharmaceutics, 2020
Cell-surface proteins that can endocytose into brain microvascular endothelial cells serve as promising candidates for receptor-mediated transcytosis across the blood–brain barrier (BBB).
Shingo Ito, Mariko Oishi, Seiryo Ogata, Tatsuki Uemura, Pierre-Olivier Couraud, Takeshi Masuda, Sumio Ohtsuki   +6 more
doaj   +1 more source

Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. [PDF]

PLoS ONE, 2012
The invasive ability of the blood-borne fungal pathogen Cryptococcus neoformans can be enhanced through interactions with host plasma components, such as plasminogen.
Jamal Stie, Deborah Fox
doaj   +1 more source

Role of Microvascular Endothelial Cells in Inflammation

Journal of Investigative Dermatology, 1993
Endothelial cells are critical elements in the evolution of all types of cutaneous inflammation. They participate through the synthesis and secretion of pro-inflammatory cytokines, including interleukin 1 (IL-1), IL-6, and IL-8, as well as M-CSF, G-CSF, GM-CSF, gro alpha, and MCP.
Swerlick, Robert A., Lawley, Thomas J.
openaire   +2 more sources

Shear Stress Rescued the Neuronal Impairment Induced by Global Cerebral Ischemia Reperfusion via Activating PECAM-1-eNOS-NO Pathway

Frontiers in Cell and Developmental Biology, 2021
Microvessel hypoperfusion following ischemic stress resulted in a decreased shear stress of brain microvascular endothelial cells (BMECs) and contributed to abnormal expression of PECAM-1 after global cerebral ischemia/reperfusion (I/R) injury.
Jing-Quan Gao, Peng Wang, Jun-Wei Yan, Li-Na Ba, Pi-Long Shi, Hong-Mei Wu, Xue-Ying Guan, Yong-gang Cao, Hong-Li Sun, Xiao-Yuan Mao, Xiao-Yuan Mao   +10 more
doaj   +1 more source

Radiation-induced apoptosis in microvascular endothelial cells [PDF]

British Journal of Cancer, 1997
The response of the microvasculature to ionizing radiation is thought to be an important factor in the overall response of both normal tissues and tumours. It has recently been reported that basic fibroblast growth factor (bFGF), a potent mitogen for endothelial cells, protects large vessel endothelial cells from radiation-induced apoptosis in vitro ...
R E, Langley, E A, Bump, S G, Quartuccio, D, Medeiros, S J, Braunhut   +4 more
openaire   +2 more sources

Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions

Cellular & Molecular Biology Letters, 2023
Background Hematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dysfunction. While much emphasis is on the reconstitution of hematopoietic stem cells in the bone marrow microenvironment ...
Seyram Yao Adzraku, Guozhang Wang, Can Cao, Yurong Bao, Yizhou Wang, Alhaji Osman Smith, Yuwei Du, Haiyang Wang, Yue Li, Kailin Xu, Jianlin Qiao, Wen Ju, Lingyu Zeng   +12 more
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Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Journal of Neuroinflammation, 2018
Background Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory product. Protease-activated receptor 2
Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian   +5 more
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Plasmodium falciparum Parasite Lines Expressing DC8 and Group A PfEMP1 Bind to Brain, Intestinal, and Kidney Endothelial Cells

Frontiers in Cellular and Infection Microbiology, 2022
Cytoadhesion of Plasmodium falciparum-infected red blood cells is a virulence determinant associated with microvascular obstruction and organ complications.
Luana S. Ortolan, Marion Avril, Jun Xue, Karl B. Seydel, Karl B. Seydel, Ying Zheng, Joseph D. Smith, Joseph D. Smith   +7 more
doaj   +1 more source