Results 11 to 20 of about 204,813 (306)

Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke

open access: yesNeural Regeneration Research, 2015
Brain microvascular endothelial cells form the interface between nervous tissue and circulating blood, and regulate central nervous system homeostasis. Brain microvascular endothelial cells differ from peripheral endothelial cells with regards expression
Qi-jin Yu   +3 more
doaj   +3 more sources

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

open access: yesNature Communications, 2023
Vascular mechanisms of Alzheimer’s disease (AD) may constitute a therapeutically addressable biological pathway underlying dementia. We previously demonstrated that soluble pathogenic forms of tau (tau oligomers) accumulate in brain microvasculature of ...
Stacy A. Hussong   +15 more
doaj   +2 more sources

Mechanisms of modulation of brain microvascular endothelial cells function by thrombin. [PDF]

open access: yesBrain Research, 2017
Brain microvascular endothelial cells are a critical component of the blood-brain barrier. They form a tight monolayer which is essential for maintaining the brain homeostasis.
Abood, Mary E.   +4 more
core   +4 more sources

Immunomagnetic Isolation and Enrichment of Microvascular Endothelial Cells from Human Adipose Tissue

open access: yesBio-Protocol, 2022
Human adipose tissue-resident microvascular endothelial cells are not only garnering attention for their emergent role in the pathogenesis of obesity-related metabolic disorders, but are also of considerable interest for vascular tissue engineering due ...
Jeremy Antonyshyn   +6 more
doaj   +1 more source

Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro

open access: yesPharmaceutics, 2020
Cell-surface proteins that can endocytose into brain microvascular endothelial cells serve as promising candidates for receptor-mediated transcytosis across the blood–brain barrier (BBB).
Shingo Ito   +6 more
doaj   +1 more source

Induction of brain microvascular endothelial cell urokinase expression by Cryptococcus neoformans facilitates blood-brain barrier invasion. [PDF]

open access: yesPLoS ONE, 2012
The invasive ability of the blood-borne fungal pathogen Cryptococcus neoformans can be enhanced through interactions with host plasma components, such as plasminogen.
Jamal Stie, Deborah Fox
doaj   +1 more source

Diabetes mellitus and ischemic heart disease. the role of ion channels [PDF]

open access: yes, 2018
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic ...
De Marchis, Marialaura   +8 more
core   +2 more sources

Radiation-induced apoptosis in microvascular endothelial cells [PDF]

open access: yesBritish Journal of Cancer, 1997
The response of the microvasculature to ionizing radiation is thought to be an important factor in the overall response of both normal tissues and tumours. It has recently been reported that basic fibroblast growth factor (bFGF), a potent mitogen for endothelial cells, protects large vessel endothelial cells from radiation-induced apoptosis in vitro ...
R E, Langley   +4 more
openaire   +2 more sources

Signaling from blood vessels to CNS axons through nitric oxide [PDF]

open access: yes, 2006
Brain function is usually perceived as being performed by neurons with the support of glial cells, the network of blood vessels situated nearby serving simply to provide nutrient and to dispose of metabolic waste.
Bartus, K   +6 more
core   +1 more source

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells [PDF]

open access: yes, 2020
Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable.
Bultynck, Geert   +10 more
core   +1 more source

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