TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior +5 more
wiley +1 more source
Stem cell-derived extracellular vesicles as immunomodulators: a novel paradigm for post-myocardial infarction repair and regeneration. [PDF]
Raza A +6 more
europepmc +1 more source
Biogenesis of TNF‐α‐insights into proteostasis and inflammation
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Unveiling the potential of extracellular and outer membrane vesicles in fish aquaculture: a comprehensive review. [PDF]
Park SY +4 more
europepmc +1 more source
Mast Cells Selectively Deliver Extracellular Vesicle‐Encapsulated mRNA to Colorectal Cancer Cells
Schematic overview of mast cell‐colorectal cancer cell interactions. Mast cells bind to colorectal cancer cells through integrin‐mediated adhesion (1). Calcium influx arises in mast cells (2). Calcium signaling is required for the release of mRNA‐ and protein‐containing vesicles (3), resulting in the transfer of mast cell‐derived mRNA and proteins to ...
Rosie Lanzloth +4 more
wiley +1 more source
EV-Mediated Oncogenic Regulation in Lung Cancer and Clinical Translation: From Liquid Biopsy to Targeted Delivery Systems. [PDF]
Fang J +6 more
europepmc +1 more source
Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai +2 more
wiley +1 more source
Artificial intelligence and extracellular vesicles in oncology: towards tumor diagnosis, prediction, and therapy. [PDF]
Li X +8 more
europepmc +1 more source
Do Exercise‐Induced Extracellular Vesicles Carry Cognitive Benefits to the Brain?
Exercise‐induced muscle‐brain communication mediated by extracellular vesicles. Physical exercise stimulates skeletal muscle to release extracellular vesicles (EVs) into the circulation. These vesicles may reach the brain and transfer bioactive cargo such as miRNA, thereby supporting neuronal function and brain homeostasis and potentially protecting ...
Oliver K. Fuller, Thierry Galli
wiley +1 more source

