Results 141 to 150 of about 51,554 (307)

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Development of Pre-Vascularized Tissues Containing Aligned and Perfusable Microvessels

, 2016
University of Minnesota Ph.D. dissertation. May 2016. Major: Chemical Engineering. Advisor: Robert Tranquillo. 1 computer file (PDF); viii, 144 pages.The single greatest restraint in tissue engineering is the inability to create and perfuse functional ...
Riemenschneider, Sonja
core  

Isolation of morphologically and functionally intact gastric mucosal microvessels rapid communication. [PDF]

, 2000
Gastric mucosal microvessels were isolated after arterial perfusion of the rat stomach with magnetized iron oxide suspension. After homogenization of scrapped gastric mucosa, microvessels were initially separated with a high power magnet and further ...
Ichikawa, Y., Sarfeh, I.J., Arakawa, T., Szabo, I., Sekhon, S, Szabo, I, Ichikawa, Y, Arakawa, T, Tarnawski, A, Sekhon, S., Sarfeh, I J, Tarnawski, A.   +11 more
core  

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

ICAM-1 expression in lung microvessels.

, 2013
A–E Confocal images show immunofluorescence of ICAM-1 in lung microvessels following treatments as indicated. Treatment durations were as outlined in Methods. v-venule, c-capillary. Scale bar = 20 µm.
Kaushik Parthasarathi (411901), Lavanya Bezavada (411899), Rachel B. Escue (411900), Kathirvel Kandasamy (411898)   +3 more
core   +1 more source

Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang, Man‐Hou Chao, Xin Luo, Feng‐Wen Shan, Zi‐Xuan Hua, Ze‐Zhi Guo, Hua‐Mei Yan, He Zhang, Tong Wu, Min Zhou, Rui Zheng, Shuo Wu, Xue‐Kun Huang, Zhao‐Hui Shi, Ya‐Na Zhang, Ji Yang, Qin‐Tai Yang   +16 more
wiley   +1 more source

Isolation and Imaging of Microvessels From Brain Tissue

Bio-Protocol
Proper brain function depends on the integrity of the blood–brain barrier (BBB), which is formed by a specialized network of microvessels in the brain. Reliable isolation of these microvessels is crucial for studying BBB composition and function in both ...
Josephine Buff, Carolyn Bertozzi, Tony Wyss-Coray, Sophia Shi   +3 more
doaj   +1 more source

Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling

Andrology, EarlyView.
ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu, Peng Hu, Zizhong Yang, Zhenghui Jin, Xiaoyu Zhu, Tao Wang, Jihong Liu, Kai Cui   +7 more
wiley   +1 more source

COMP-Ang-1 dependent regeneration of endoneural microvessels in ob/ob mice.

, 2013
COMP-Ang-1 treatment enhanced densities of small-diameter endoneural microvessels in ob/ob mice. Endoneural microvessels were visualized by FITC injection (10 mg/ml).
Joanna Kosacka (330426), Michael Stumvoll (103716), Matthias Blüher (103713), Matthias Kern (190843), Marcin Nowicki (109802), Ingo Bechmann (109810), Heike Serke (330427), Nora Klöting (230996)   +7 more
core   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source