Results 151 to 160 of about 46,194 (267)

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Downregulation of <i>Trpv4</i> and <i>Klf2</i> in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction. [PDF]

J Cereb Blood Flow Metab
Lambrichts SM, van der Taelen L, Pastor I, Leenders P, Bitsch N, Majcher D, Hermes D, Simmonds SJ, van Herwijnen M, Kamps R, Weltjens E, Jessen PJ, Steinbusch HP, Arentz F, Wiesmann M, Kiliaan AJ, Caiment F, Kutmon M, Jones EA, van Oostenbrugge RJ, Foulquier S.   +20 more
europepmc   +1 more source

microRNA‐145‐5p regulates P‐glycoprotein and breast cancer resistance protein in primary human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye, Enrrico Bloise, Nikola Ivanovski, Lubna Nadeem, Christopher Casciaro, Stephen G. Matthews   +5 more
wiley   +1 more source

Association Between Cardiovascular Risk Factors and Pan-Coronary Plaque Burden, Phenotype, and Vulnerability: A 3-Vessel Imaging Study. [PDF]

JACC Adv
Chmiel J, Andreaggi S, Kim S, McNulty I, Lee H, Banning AP, Bryniarski KL, Musialek P, Jang IK.   +8 more
europepmc   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

White Globe Appearance Is an Endoscopic Predictor of Metachronous Multiple Gastric Cancers

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives White globe appearance (WGA) is a small white lesion with a globular shape identified during magnifying endoscopy with narrow‐band imaging. However, the association between WGA and metachronous gastric cancer remains unclear. Methods This study involved patients who underwent endoscopic submucosal dissection (ESD) for first‐episode ...
Manami Utsunomiya, Hiroyoshi Nakanishi, Naohiro Yoshida, Saori Miyajima, Azusa Kawasaki, Shigenori Wakita, Yosuke Kito, Kunihiro Tsuji, Haruhiko Shugo, Shigetsugu Tsuji, Sho Tsuyama, Kazuyoshi Katayanagi, Hiroshi Minato, Hisashi Doyama   +13 more
wiley   +1 more source

Longitudinal three-dimensional photoacoustic imaging reveals hyperoxic perilesional microvasculature associated with keloid recurrence. [PDF]

Photoacoustics
Makino A, Saito S, Takaya A, Kosaka T, Sawaragi E, Munisso MC, Yoshikawa A, Asao Y, Sekiguchi H, Yagi T, Morimoto N.   +10 more
europepmc   +1 more source

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, Volume 65, Issue 11, Page 1383-1397, November 2026.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro-Inflammatory Endothelial Cells. [PDF]

Adv Sci (Weinh)
Xia J, Wang WY, Jacobs KA, Maniar K, Lin D, Jarman EH, Matera DL, Loesel K, Davidson CD, Hiraki HL, Tan X, Shikanov EH, Kent RN, Parent C, Fan X, Shikanov A, Kutys ML, Baker BM.   +17 more
europepmc   +1 more source

AI‐based anatomical recognition for bladder neck dissection in robot‐assisted radical prostatectomy

BJU International, Volume 138, Issue 5, Page 852-859, November 2026.
Objective To develop an artificial intelligence (AI) system for anatomical recognition that can automatically identify key anatomical structures during bladder neck dissection in robot‐assisted radical prostatectomy (RARP), a critical yet technically demanding step.
Shinnosuke Fujiwara, Keishiro Fukumoto, Masashi Takeuchi, Yuichiro Konnai, Yota Yasumizu, Nobuyuki Tanaka, Toshikazu Takeda, Kazuhiro Matsumoto, Takeo Kosaka, Hirofumi Kawakubo, Masaru Ishida, Yuko Kitagawa, Mototsugu Oya   +12 more
wiley   +1 more source