Results 121 to 130 of about 152,722 (386)

Investigating the Relationship Between Midazolam Serum Concentrations and Paediatric Delirium in Critically Ill Children

Pediatric Reports
Objectives: Intravenous midazolam is widely used for sedation in critically ill children. Sometimes, these children develop a paediatric delirium (PD). Our aim was to determine the relationship between midazolam serum concentration and the development of
Sabrina Marongiu, Mathieu S. Bolhuis, Daan J. Touw, Martin C. J. Kneyber   +3 more
doaj   +1 more source

CARIES TREATMENT OF A MIDAZOLAM-PREMEDICATED PATIENT WITH DEVELOPMENTAL DISORDERS : A CASE REPORT [PDF]

, 2013
Hyoeun Kim, Teo-Jeon Shin, Young-Jae Kim, Jung‐Wook Kim, Ki‐Taeg Jang, Sanghoon Lee, Chong‐Chul Kim, Hong‐Keun Hyun   +7 more
openalex   +1 more source

An Evaluation of the Drug Interaction Potential of Encorafenib in Combination With Binimetinib Using the Inje Cocktail in Patients With Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
A clinical drug–drug interaction (DDI) study was designed to evaluate the effect of single and multiple oral doses of encorafenib on the single oral dose pharmacokinetics (PK) of the cytochrome P450 (CYP) enzyme probe substrates, losartan (CYP2C9), midazolam (CYP3A4), caffeine (CYP1A2), omeprazole (CYP2C19), and dextromethorphan (CYP2D6) administered ...
Joseph Piscitelli, Micaela B. Reddy, Lance Wollenberg, Laurence Del Frari, Jason Gong, Kyle Matschke, Jason H. Williams   +6 more
wiley   +1 more source

Treatment of agitation in terminally ill patients with intranasal midazolam versus subcutaneous midazolam: study protocol for a randomised controlled open-label monocentric trial (MinTU Study)

BMC Palliative Care
Background Intranasal (i.n.) drug application is a widely known and low-invasive route of administration that may be able to achieve rapid symptom control in terminally ill patients. According to the German S3 guideline “Palliative care for patients with
Hanna Hirschinger, Evelyn Jaeger, Stefanie Nittka, Svetlana Hetjens, Christine Lorenz, Constanze Remi, Susanne Saussele, Wolf-K. Hofmann, Deniz Gencer, Tobias Boch   +9 more
doaj   +1 more source

The influence of age on the onset of anaesthesia with midazolam [PDF]

, 1985
JOHN W. DUNDEE, N. J. Halliday, P. G. Loughran, K. W. Harper   +3 more
openalex   +1 more source

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, EarlyView.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Efficacy and Safety of Nebulized Midazolam versus Oral Midazolam as Sedative Premedication in Pediatric Surgeries

Journal of Current Ophthalmology
Purpose: To compare the effectiveness of midazolam premedication administered through nebulization and orally as premedication in pediatric anesthesia in ophthalmic surgeries.
Abbas Ostadalipour, Anahid Maleki, Bita Malekianzadeh, Motahhareh Sadeghi, Alireza Takzare, Nima Nazari, Sumaiya Zahra, Armin Sahba, Parisa Kianpour, Saghar Samimi   +9 more
doaj   +1 more source

PERBANDINGAN PERUBAHAN LAJU NADI PADA PREMEDIKASI ANTARA DIAZEPAM DAN MIDAZOLAM PADA SPINAL ANESTESI [PDF]

, 2015
Iwing Dwi Purwandi, G0099094, 2006 PERBANDINGAN PERUBAHAN LAJU NADI PADA PREMEDIKASI ANTARA DIAZEPAM DAN MIDAZOLAM PADA SPINAL ANESTESI, Fakultas Kedokteran Universitas Sebelas Maret Dalam anestesiologi, tindakan monitoring sangat vital dalam menjaga ...
PURWANDI, IWING DWI
core  

Embryonic cerebrospinal fluid pressure in fetal mice in utero: External factors pressurize the intraventricular space

Developmental Dynamics, EarlyView.
Abstract Background Previous experiments inducing leakage of embryonic cerebrospinal fluid (CSF) suggest the necessity of intraventricular CSF pressure (PCSF) for brain morphogenesis. Nevertheless, how embryonic PCSF occurs is unclear, especially in utero. Results Using a Landis water manometer, we measured PCSF in fetal mice isolated from the amniotic
Koichiro Tsujikawa, Reina Muramatsu, Takaki Miyata   +2 more
wiley   +1 more source