Results 101 to 110 of about 79,032 (289)

Oral administration of a low dose of midazolam (75μg) as an in vivo probe for CYP3A activity [PDF]

, 2018
Objective: We investigated whether the oral administration of a low dose (75µg) of midazolam, a CYP3A probe, can be used to measure the in vivo CYP3A activity.
Aubert, Anne-Catherine, Bleiber, Gabriela, Baumann, Pierre, Eap, Chin, Zullino, Daniele, Telenti, Amalio, Kerb, Reinhold, Hustert, Elisabeth, Cucchia, Gianni, Golay, Kerry, Buclin, Thierry   +10 more
core  

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2‐Related Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata, Chhitij Tiwari, Zheng Fan, Muge Gucsavas‐Calikoglu, Yael Shiloh‐Malawsky, Kimberly S. Foss, Stephanie N. Peck, Erin L. Heinzen, Chon Lee, Senyene E. Hunter   +9 more
wiley   +1 more source

Single dose oral midazolam for minor emergency department procedures in children: a retrospective cohort study

, 2018
Gal Neuman,1,* Rana Swed Tobia,2,* Liron Koren,3 Ronit Leiba,4 Itai Shavit5 1Clinical Pharmacology and Toxicology Unit, 2Department of Pediatrics, Ruth Children’s Hospital, Rambam Health Care Campus, 3Rappaport Faculty of Medicine, Technion –
Koren L, Shavit I, Neuman G, Swed Tobia R, Leiba R   +4 more
core  

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

Unbound Intrinsic Formation Clearance of 6β‐Hydroxycortisol Is a Useful Biomarker of CYP3A4 Activity during Pregnancy

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy results in multiple physiological changes that impact drug disposition. For example, hepatic CYP3A activity and renal transporter‐mediated clearance increase in late pregnancy, but the time course of these changes across pregnancy is not known.
Aurora K Authement, Mary F Hebert, Emily E Fay, Nina Isoherranen   +3 more
wiley   +1 more source

Monitoring Injected Drug Use in Greece Through Syringe Residue Analysis: A Multicity Study Within the ESCAPE Network

Drug Testing and Analysis, EarlyView.
A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki, Anastasios Trakakis, Athanasios Theocharis, Chara Parpala, Chara Kotsailidou, Alexandros Psarianos, Emmanouil Chatzichristofis, Eleni Zagelidu, Panagiota Roussou, Nikolaos Raikos, Orthodoxia Mastrogianni   +10 more
wiley   +1 more source

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

A Comparative Study of the Effect of Midazolam-Ketamine and Midazolam-Propofol in Children 1 to 10 years old [PDF]

, 2018
Objective: The aim of this study was to evaluate the effect of midazolam-ketamine and midazolam-propofol in children aged 1 to 10 years under endoscopy.Materials and Methods: This cross-sectional study was performed on 60 children aged 1 to 10 years old ...
Ostad Alipour, Abbas, Maleki, Anahid, Spahbodi, Ebrahim, Goudarzi, Mehrdad, Ebrahim Soltani, Ali Reza, Takazare, Alireza   +5 more
core   +1 more source

Smart Functional Hydrogels: Emerging Platforms for Thermal and Electrochemical Energy Harvesting and Conversion Systems

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The hydrogel exhibits versatile functions, including efficient thermogalvanic conversion under a temperature difference, and acting as a cooling layer/forming a thermally conductive nanoactive composite for thermovoltaic conversion. Additionally, its self‐healing and self‐powered flexibility play a key role in energy storage systems. The growing demand 
Eunah Kang
wiley   +1 more source

Is Evidence‐Based Policymaking an Environmental Studies Agenda? An Interpretive Review

Environmental Policy and Governance, EarlyView.
ABSTRACT Studies of knowledge development and use for public decision‐making can be found across the social sciences. There have been increasing calls for meaningful integration of the contrasting disciplinary perspectives on this topic, including from environmental and sustainability sciences.
Peter Tangney, Raisa Adamjee
wiley   +1 more source