Results 91 to 100 of about 71,642 (287)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Midazolam sedates Passeriformes for field sampling but affects multiple venous blood analytes

, 2015
J Jill Heatley,1 Jennifer Cary,2,3 Lyndsey Kingsley,1 Hughes Beaufrere,4 Karen E Russell,5 Gary Voelker2,3 1Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, 2Department of Wildlife and Fisheries ...
Beaufrere H, Russell KE, Kingsley L, Voelker G, Heatley JJ, Cary J   +5 more
core  

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

Clinical Pharmacology &Therapeutics, EarlyView.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat, Haribhau Kangne, Rasmus Jansson‐Löfmark, Jens K. Hertel, Amin Rostami‐Hodjegan, Ida Robertsen, Aleksandra Galetin   +6 more
wiley   +1 more source

Treatment of agitation in terminally ill patients with intranasal midazolam versus subcutaneous midazolam: study protocol for a randomised controlled open-label monocentric trial (MinTU Study)

BMC Palliative Care
Background Intranasal (i.n.) drug application is a widely known and low-invasive route of administration that may be able to achieve rapid symptom control in terminally ill patients. According to the German S3 guideline “Palliative care for patients with
Hanna Hirschinger, Evelyn Jaeger, Stefanie Nittka, Svetlana Hetjens, Christine Lorenz, Constanze Remi, Susanne Saussele, Wolf-K. Hofmann, Deniz Gencer, Tobias Boch   +9 more
doaj   +1 more source

Mapping the US Bridgebuilding Field: Situating Organizations in the Ecosystem of Social Change

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This article explores the ecosystem of bridge‐building initiatives in the United States. Drawing on an original database of 223 organizations, interviews with 7 staff across 6 organizations, and a literature review related to bridge‐building, polarization, and collective action, we first describe the range of existing initiatives and their ...
Gabrielle Mathews, Karen Ross
wiley   +1 more source

INTRATHECAL MIDAZOLAM PROLONGS THE ANALGESIC EFFECTS OF SPINAL BLOCKADE WITH LIDOCAINE FOR PERINEAL OPERATION [PDF]

Acta Medica Iranica, 2006
Intrathecal administration of midazolam has been reported to have antinociceptive action, and to be an effective analgesic agent. In this prospective double-blind study we aimed to evaluate the postoperative effects of intrathecal midazolam with ...
B. Jahangiri R. Jahangiri
doaj  

A phenomap of TTR amyloidosis to aid diagnostic screening

ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos   +4 more
wiley   +1 more source

Efficacy and Safety of Nebulized Midazolam versus Oral Midazolam as Sedative Premedication in Pediatric Surgeries

Journal of Current Ophthalmology
Purpose: To compare the effectiveness of midazolam premedication administered through nebulization and orally as premedication in pediatric anesthesia in ophthalmic surgeries.
Abbas Ostadalipour, Anahid Maleki, Bita Malekianzadeh, Motahhareh Sadeghi, Alireza Takzare, Nima Nazari, Sumaiya Zahra, Armin Sahba, Parisa Kianpour, Saghar Samimi   +9 more
doaj   +1 more source

Influência da duração da primeira exposição de ratos ao labirinto em cruz elevado no aumento da esquiva dos braços abertos e efeito do Midazolam na segunda exposição [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.O objetivo deste estudo foi avaliar a influência da duração da primeira exposição (E1) no aumento da esquiva dos ...
Dal-Cól, Maria Luiza Cleto
core  

Hypersensitivity Reaction to Midazolam

, 2015
International audienceThe incidence of hypersensitivity due to anesthesia in children is 1/7741. Hypersensitivity reactions are a result of either an immunologic mechanism (allergic or anaphylactic reaction) generally mediated by immunoglobulines E (IgE)
Montagut, F, Tran, Tu-Anh, Filleron, Anne, Kumba, C, Ripart, J, Valade, N   +5 more
core   +1 more source