Results 251 to 260 of about 182,279 (337)

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

Optogenetic stimulation of midbrain dopaminergic neurons rescues hippocampal synaptic plasticity deficits in a mouse model of Alzheimer's disease. [PDF]

Transl Psychiatry
Ficchì S, Cauzzi E, La Barbera L, De Paolis ML, Loffredo G, Spoleti E, Ferrari I, Saba L, Biamonte F, Nobili A, Krashia P, D'Amelio M.   +11 more
europepmc   +1 more source

Heterologous Production of Forskolin in Tobacco (Nicotiana tabacum) via Glandular Trichome Specific Engineering and Metabolic Flux Redirection

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plants are promising bioreactor for the sustainable and scalable production of high‐value natural bioactive compounds, because they can synthesise phytochemicals from CO2, light, water and minerals through their innate photosynthetic carbon assimilation machinery.
Xuan Sun, Xiuming Wu, Xun Jiang, Hongmei Huang, Aiguo Yang, Yiting Li, Zhenjun Fan, Aixia Chang, Changqing Yang   +8 more
wiley   +1 more source

Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics

, 2018
Vincent Croset, Christoph D. Treiber, Scott Waddell   +2 more
openalex   +1 more source

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, EarlyView.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

A Case of Bilateral Trochlear Nerve Palsy Induced by a Dorsal Midbrain Intracranial Lipoma. [PDF]

Cureus
Kawamura J, Shimizu Y, Tabuchi H.
europepmc   +1 more source

Trouble in the Tank: A Case Report of Fatal Scuticociliate Encephalitis in a Whitetip Reef Shark (Triaenodon obesus)

Journal of Fish Diseases, EarlyView.
Hella Schwegler, Jeff Schreiner, Maria Prüllage, Karoline Lipnik, Astrid S. Holzer, Eva Lewisch   +5 more
wiley   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Artery of Percheron Infarction: Diagnostic and Clinical Insights From Two Cases. [PDF]

Cureus
Thomas AZ, Krishnan A, Joseph H, Sreekumar A, Jayachandran V, Mathew P.   +5 more
europepmc   +1 more source

Midbrain ganglioglioma

, 2021
openaire   +1 more source