Results 251 to 260 of about 212,558 (382)

PBX1 Improves Cognition and Reduces Amyloid‐β Pathology in APP/PS1 Mice by Transcriptionally Activating the CRTC2–CREB Pathway

Aging Cell, EarlyView.
We found that the transcription factor PBX1 is markedly downregulated in patients with Alzheimer's disease and in disease models. Restoring PBX1 reduces Aβ pathology and rescues cognitive deficits. Mechanistically, PBX1 directly activates the transcription of CRTC2 and enhances p‐CREB signaling, thereby conferring neuroprotection.
Zinan Liu, Xiangyuan Meng, Rifeng Lu, Xiaoting Meng, Siyao Li, Yujie Wang, Xinpeng Liu, Xiaomei Liu, Jinyu Liu   +8 more
wiley   +1 more source

In vitro derivation of midbrain dopaminergic neurons from porcine embryonic stem cells in multi-dimensional conditions. [PDF]

Stem Cell Res Ther
Choi H, Oh D, Jawad A, Haomiao Z, Ham J, Heo J, Oh A, Jin H, Seo J, Oh BC, Hyun SH.   +10 more
europepmc   +1 more source

Potential TMS biomarkers for GABAB receptor engagement in alcohol use disorder: A systematic review of existing evidence

Alcohol, Clinical and Experimental Research, EarlyView.
This systematic review emphasizes the critical role of GABAB receptors (GABABR) in alcohol use disorder (AUD). While GABABR agonists enhance cortical inhibition, as measured by transcranial magnetic stimulation (TMS)‐based markers, alcohol consumption alters GABABR ‐dependent neurophysiological measures, suggesting GABABR dysfunction plays a key role ...
Chiara Montemitro, Sara Terrezza, Federico Maruottolo, Andrea Costumati, Markus Heilig   +4 more
wiley   +1 more source

Artery of Percheron infarct with multiple cranial nerve palsies and Horner Syndrome. [PDF]

Am J Ophthalmol Case Rep
Sanfelippo WA, Oley M, Harrelson H, Vilar N.   +3 more
europepmc   +1 more source

Primary catastrophic antiphospholipid syndrome in children with midbrain infarction: a case report [PDF]

Qinghua Dong, Jianyun Yin, Hang Su, Qian Ni   +3 more
openalex   +1 more source

Alzheimer's disease and mixed pathologies as a hidden contributor to fatal hypothermia: A large‐scale forensic autopsy‐based study

Brain Pathology, EarlyView.
We investigated neuropathological manifestations of hypothermia in 168 cases. Patients aged 65 years or more constituted 80% of the total cohort. Alzheimer's disease was the most common comorbidity, affecting 40% of all patients. Abstract There is a paucity of autopsy‐based studies providing detailed neuropathological characteristics of fatal ...
Shojiro Ichimata, Koji Yoshida, Ryo Tanaka   +2 more
wiley   +1 more source

Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity. [PDF]

Commun Biol
Tao J, Antoine D, Jalodia R, Valdes E, Boyles SM, Hulme W, Roy S.   +6 more
europepmc   +1 more source

The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system

, 2015
Edgar R. Kramer
openalex   +1 more source

Sensitization of Midbrain Dopamine Neuron Reactivity Promotes the Pursuit of Amphetamine [PDF]

, 2002
Paul Vezina, Daniel S. Lorrain, Gretchen Arnold, Jennifer D. Austin, Nobuyoshi Suto   +4 more
openalex   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source