Results 271 to 280 of about 182,279 (337)

Differentiating Creatine and Phosphocreatine In Vivo Using 3 T 1H MR Spectroscopy

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 1896-1906, April 2026.
ABSTRACT Purpose Validation and improvements to the proton MR spectroscopic measurement of creatine and phosphocreatine in vivo at 3 T. Methods Spectral simulations were used to evaluate and explore the mitigation of LCModel fitting bias due to lineshape, signal‐to‐noise (SNR) and non‐metabolite backgrounds with a focus on phosphocreatine and the ...
Ralph E. Hurd, Meng Gu, Philip M. Adamson, Kenichi Okamura, Masafumi Shibata, Yoshikazu Ono, Moussa Haidar, Kirk Riemer, Frank L. Hanley, Daniel M. Spielman   +9 more
wiley   +1 more source

Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice. [PDF]

Front Pharmacol
Pajarillo E, Digman A, Ajayi I, Kim S, Son DS, Aschner M, Lee E.   +6 more
europepmc   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

Three-dimensional midbrain organoids: a next-generation tool for Parkinson's disease modelling and drug discovery. [PDF]

Stem Cell Res Ther
Elvira R, Tan EK, Zhou ZD.
europepmc   +1 more source

Altered Mechanical Properties of Astrocytes Lacking MLC1: Implications for the Leukodystrophy MLC

Glia, Volume 74, Issue 2, February 2026.
Mechanical properties of Mlc1‐null astrocytes are altered. Cytoskeleton‐related pathways are dysregulated in Mlc1‐null astrocytes. Mlc1‐null astrocytes show alterations in focal adhesions, which link the cytoskeleton to the extracellular matrix. ABSTRACT Loss of function of the astrocyte protein MLC1 causes Megalencephalic Leukoencephalopathy with ...
Quinty Bisseling, Emma M. J. Passchier, Freya M. Kirwan, Nelda Antonovaite, Serena Camerini, Maria S. Brignone, Amélie Freal, Huibert D. Mansvelder, Elena Ambrosini, Marjo S. van der Knaap, Rogier Min   +10 more
wiley   +1 more source

Reproducibility of PD patient-specific midbrain organoid data for <i>in vitro</i> disease modeling. [PDF]

iScience
Zuccoli E, Al Sawaf H, Tuzza M, Nickels SL, Zagare A, Schwamborn JC.   +5 more
europepmc   +1 more source

Exercise with induced pluripotent stem cells enhances Wnt1-Lmx1a signaling and dopaminergic neurogenesis to alleviate Parkinsonian symptoms. [PDF]

World J Stem Cells
Arafat A, Soliman SMA, Farghaly TA, Ebrahim NAA.   +3 more
europepmc   +1 more source

Differential Neural Dynamics in Psychomotor Retardation and Agitation of Depression

Human Brain Mapping, Volume 47, Issue 2, 01 February 2026.
This study investigates the dynamic functional connectivity underlying depression with psychomotor disturbance. Findings identified a differential lag propagation pattern between agitated and retarded depression related to the somatomotor network.
Qunjun Liang, Ziyun Xu, Shengli Chen, Shiwei Lin, Xiaoshan Lin, Ying Li, Yingli Zhang, Bo Peng, Gangqiang Hou, Yingwei Qiu, Georg Northoff   +10 more
wiley   +1 more source

The Unusual Suspect: Artery of Percheron Occlusion in a Young Healthy Patient. [PDF]

Cureus
Zon MTH, Lwin KWY, Owolabi O, Omer S.
europepmc   +1 more source

The Ontogenetic Development of Rapid Eye Movement Sleep in Early Life and Its Regulatory Mechanisms

International Journal of Developmental Neuroscience, Volume 86, Issue 1, February 2026.
REM sleep was first identified in humans and cats in the late 1950s and exhibits a conserved developmental trajectory across species. This study elucidates key characteristic changes during REM sleep development, thereby providing a foundation for improving the prevention and treatment of various neurodevelopmental disorders.
Xiu‐Juan Zhang, Xu‐Hao Gao, An‐Hong Wang, Cai‐Qin Wang, Jia Liu, Yan‐Li Hu, Bo‐Wen Duan, Hai‐Yun Huang, Jin‐Xian Gao   +8 more
wiley   +1 more source