Results 51 to 60 of about 66,034 (171)

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Middle East Respiratory Syndrome Coronavirus Disease in Children

Pediatric Infectious Disease Journal, 2014
In the initial description of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, many affected patients were adults with underlying medical comorbidities. Data on the clinical presentation and outcome of pediatric cases are lacking.
Ziad A, Memish, Jaffar A, Al-Tawfiq, Abdullah, Assiri, Fahad A, AlRabiah, Sami, Al Hajjar, Ali, Albarrak, Hesham, Flemban, Rafat F, Alhakeem, Hatem Q, Makhdoom, Sarah, Alsubaie, Abdullah A, Al-Rabeeah   +10 more
openaire   +3 more sources

Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus [PDF]

Emerging Infectious Diseases, 2019
Middle East respiratory syndrome coronavirus (MERS-CoV) was detected in humans in 2012. Since then, sporadic outbreaks with primary transmission through dromedary camels to humans and outbreaks in healthcare settings have shown that MERS-CoV continues to pose a threat to human health.
Harvey, Ruth, Mattiuzzo, Giada, Hassall, Mark, Sieberg, Andrea, Müller, Marcel A., Drosten, Christian, Rigsby, Peter, Caly, L., Li, C., Zhao, L., Tan, W., Peiris, M., Perera, M., Kang, C., Wang, J. S., Haagmans, B., Okba, N. M.A., Gopal, R., Myhill, S., Thornburg, N.   +19 more
openaire   +4 more sources

Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014

Emerging Infectious Diseases, 2015
We investigated an outbreak of Middle East respiratory syndrome (MERS) at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, during March 29–May 21, 2014.
Shamsudeen F. Fagbo, Leila Skakni, Daniel K.W. Chu, Musa A. Garbati, Mercy Joseph, Ahmed M. Hakawi   +5 more
doaj   +1 more source

Characterization and immunogenicity of nanoparticle vaccines displaying embecovirus spike proteins

Biotechnology Progress, EarlyView.
Virus‐like particle vaccines displaying spike proteins from OC43, HKU1 A, and HKU1 B were evaluated in mice for their ability to elicit antibodies against the spike proteins from OC43, HKU1 A, HKU1 B, and HKU1 C. Abstract Endemic human coronaviruses OC43 and HKU1 cause widespread respiratory infections and can be associated with severe illness in ...
Peter J. Halfmann, Augustine Duffy, Alex Wee, Noah Anderson, Jackson Terrell, Yoshihiro Kawaoka, Ravi S. Kane   +6 more
wiley   +1 more source

Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus

New England Journal of Medicine, 2013
In September 2012, the World Health Organization reported the first cases of pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). We describe a cluster of health care-acquired MERS-CoV infections.Medical records were reviewed for clinical and demographic information and determination of potential contacts and exposures.
Assiri, Abdullah, McGeer, Allison, Perl, Trish M., Price, Connie S., Al Rabeeah, Abdullah A., Cummings, Derek A.T., Alabdullatif, Zaki N., Assad, Maher, Almulhim, Abdulmohsen, Makhdoom, Hatem, Madani, Hossam, Alhakeem, Rafat, Al-Tawfiq, Jaffar A., Cotten, Matthew, Watson, Simon J., Kellam, Paul, Zumla, Alimuddin I., Memish, Ziad A.   +17 more
openaire   +2 more sources

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits [PDF]

Journal of Virology, 2015
ABSTRACT The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV.
Haagmans, Bart L, van den Brand, Judith M A, Provacia, Lisette B, Raj, V Stalin, Stittelaar, Koert J, Getu, Sarah, de Waal, Leon, Bestebroer, Theo M, Amerongen, Geert van, Verjans, Georges M G M, Fouchier, Ron A M, Smits, Saskia L., Kuiken, Thijs, Osterhaus, Albert D M E   +13 more
openaire   +3 more sources

The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”

Journal of the Formosan Medical Association, 2013
A novel lineage C betacoronavirus, originally named human coronavirus EMC/2012 (HCoV-EMC) and recently renamed Middle East respiratory syndrome coronavirus (MERS-CoV), that is phylogenetically closely related to Tylonycteris bat coronavirus HKU4 and ...
Jasper Fuk-Woo Chan, Susanna Kar-Pui Lau, Patrick Chiu-Yat Woo   +2 more
doaj   +1 more source