Results 61 to 70 of about 66,034 (171)

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, EarlyView.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus [PDF]

mBio, 2014
ABSTRACT The Middle East respiratory syndrome coronavirus (MERS-CoV) was first documented in the Kingdom of Saudi Arabia (KSA) in 2012 and, to date, has been identified in 180 cases with 43% mortality. In this study, we have determined the MERS-CoV evolutionary rate, documented genetic variants of the virus and their distribution
Cotten, M, Watson, SJ, Zumla, AI, Makhdoom, HQ, Palser, AL, Ong, SH, Al Rabeeah, AA, Alhakeem, RF, Assiri, A, Al-Tawfiq, JA, Albarrak, A, Barry, M, Shibl, A, Alrabiah, FA, Hajjar, S, Balkhy, HH, Flemban, H, Rambaut, A, Kellam, P, Memish, ZA   +19 more
openaire   +4 more sources

Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea

Emerging Infectious Diseases, 2015
We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests.
Wan Beom Park, Ranawaka A.P.M. Perera, Pyoeng Gyun Choe, Eric H.Y. Lau, Seong Jin Choi, June Young Chun, Hong Sang Oh, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Leo Lit Man Poon, Ghazi Kayali, Myoung-don Oh   +15 more
doaj   +1 more source

Middle East respiratory syndrome (MERS) coronavirus and dromedaries

The Veterinary Journal, 2017
Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease that can be transmitted from dromedaries to human beings. More than 1500 cases of MERS have been reported in human beings to date. Although MERS has been associated with 30% case fatality in human beings, MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic.
Wernery, U, Lau, SKP, Woo, PCY
openaire   +4 more sources

Women in space: A review of known physiological adaptations and health perspectives

Experimental Physiology, EarlyView.
Abstract Exposure to the spaceflight environment causes adaptations in most human physiological systems, many of which are thought to affect women differently from men. Since only 11.5% of astronauts worldwide have been female, these issues are largely understudied.
Millie Hughes‐Fulford, Danielle J. Carroll, Heather C. M. Allaway, Bonnie J. Dunbar, Aenor J. Sawyer   +4 more
wiley   +1 more source

Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase

mSphere, 2016
Middle East respiratory syndrome coronavirus (MERS-CoV) helicase is a superfamily 1 helicase containing seven conserved motifs. We have cloned, expressed, and purified a Strep-fused recombinant MERS-CoV nonstructural protein 13 (M-nsp13) helicase ...
Adeyemi O. Adedeji, Hilary Lazarus
doaj   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Middle East Respiratory Syndrome Coronavirus Outbreaks

, 2023
Middle East respiratory syndrome coronavirus (MERS-CoV) is a single-stranded RNA-enveloped virus that belongs to the Coronaviridae family. Initially reported in 2012 in Saudi Arabia, MERS-CoV is a zoonotic virus originating from bats and transmitted from camels to humans and among humans by contact.
Abdulkarim F. Alhetheel, Faisal A. Alhetheel   +1 more
openaire   +1 more source

Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2017–2018

Emerging Infectious Diseases, 2019
We characterized exposures and demographics of Middle East respiratory syndrome coronavirus cases reported to the Saudi Arabia Ministry of Health during July 1–October 31, 2017, and June 1–September 16, 2018.
Ahmed Hakawi, Erica Billig Rose, Holly M. Biggs, Xiaoyan Lu, Mutaz Mohammed, Osman Abdalla, Glen R. Abedi, Ali A. Alsharef, Aref Ali Alamri, Samar Ahmad Bereagesh, Kamel M. Al Dosari, Saad Abdullah Ashehri, Waad Ghassan Fakhouri, Saleh Zaid Alzaid, Stephen Lindstrom, Susan I. Gerber, Abdullah Asiri, Hani Jokhdar, John T. Watson   +18 more
doaj   +1 more source

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong, Zaiyong Zheng, Min Huang, Shengyu Huang, Xingwei Zhao, Yang Yu, Chunxiang Zhang   +6 more
wiley   +1 more source