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High Midkine Expression Correlates with Poor Prognosis and Immune Cell Infiltration in Hepatocellular Carcinoma. [PDF]
Int J Gen MedYan L, Lv J, Xu M, Jia H, Li S.
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Cocaine perturbs neurodevelopment and increases neuroinflammation in a prenatal cerebral organoid model. [PDF]
Transl PsychiatryDavis JL +10 more
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Clinical relevance of midkine as a biomarker predicting atherosclerotic risk factors in individuals with type-2 diabetes mellitus: a cross-sectional study. [PDF]
J Diabetes Metab DisordSalman IN +5 more
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Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic canceropenaire
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Midkine: A multifaceted driver of atherosclerosis
Clinica Chimica Acta, 2021Atherosclerosis constitutes the pathological basis of life-threatening events, including heart attack and stroke. Midkine is a heparin-binding growth factor and forms a small protein family with pleiotrophin. Under inflammatory or hypoxic conditions, midkine expression is up-regulated. Upon binding to its receptors, midkine can activate multiple signal
Zi-Zhen, Zhang +3 more
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Midkine promoter-based adenoviral suicide gene therapy to midkine-positive pediatric tumor
Journal of Pediatric Surgery, 2002Suicide gene therapy based on the delivery of the herpes simplex virus thymidine kinase gene combined with ganciclovir (HSV-tk/GCV) is a promising approach for cancer treatment. Adenoviral (Ad) vectors are useful gene delivery vehicles for this approach; however, because these agents possess a high natural tropism for the liver, systems must be ...
Yasuo, Adachi +4 more
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Recognition of Glycosaminoglycans by Midkine
2003Publisher Summary This chapter describes the principal materials and methods useful for analyzing the recognition of glycosaminoglycans by midkine (MK). Two preparative methods of MK using the baculovirus system and from the culture supernatant of L cells transfected with MK cDNA are described with comments on the storage of MK solution as well MK ...
Takashi, Muramatsu +3 more
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Midkine and secondary neurulation
Teratology, 1997Midkine (MK) is a growth factor with documented neurotrophic activity for central nervous system neurons. It has also been shown to induce conversion of pluripotent mesenchymal P19 embryonic carcinoma cells into neuroepithelial derivatives. During the development of the chick embryonic neuraxis, two separate events occur.
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2012
Osteosarcoma is a malignant tumour arising from transformed cells of mesenchymal origin. It is the most common malignant bone tumour of the teenage years. Because there is no prognostic marker available except metastasis and because molecular therapy has not yet been developed in osteosarcoma, the search continues for useful biomarkers and effective ...
Tadashi Kaname +2 more
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Osteosarcoma is a malignant tumour arising from transformed cells of mesenchymal origin. It is the most common malignant bone tumour of the teenage years. Because there is no prognostic marker available except metastasis and because molecular therapy has not yet been developed in osteosarcoma, the search continues for useful biomarkers and effective ...
Tadashi Kaname +2 more
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Midkine Promotes Neuroblastoma through Notch2 Signaling
Cancer Research, 2013Abstract Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma in which MYCN is amplified remains particularly poor.
Satoshi, Kishida +8 more
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