Results 131 to 140 of about 2,564 (146)
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Journal of Neuroscience Research, 2009
AbstractMidkine (MK) is a growth factor implicated in the development and repair of various tissues, especially neural tissues. MK acts as a reparative neurotrophic factor in damaged peripheral nerves. A postulated role of MK in the degeneration and regeneration of sciatic nerves was explored by comparing wild‐type (Mdk+/+) mice with MK‐deficient (Mdk−/
Harutoshi Sakakima +2 more
exaly +4 more sources
AbstractMidkine (MK) is a growth factor implicated in the development and repair of various tissues, especially neural tissues. MK acts as a reparative neurotrophic factor in damaged peripheral nerves. A postulated role of MK in the degeneration and regeneration of sciatic nerves was explored by comparing wild‐type (Mdk+/+) mice with MK‐deficient (Mdk−/
Harutoshi Sakakima +2 more
exaly +4 more sources
Blood, 2007
Abstract Midkine (MDK), a heparin-binding growth factor, is highly expressed in pediatric ALL, neuroblastomas, and various solid tumors. Previous gene expression profiling studies conducted in our laboratory on a cohort of 220 children with B precursor ALL treated on Children’s Oncology Group (COG) clinical trials have shown that higher ...
Weihua Zeng +2 more
exaly +2 more sources
Abstract Midkine (MDK), a heparin-binding growth factor, is highly expressed in pediatric ALL, neuroblastomas, and various solid tumors. Previous gene expression profiling studies conducted in our laboratory on a cohort of 220 children with B precursor ALL treated on Children’s Oncology Group (COG) clinical trials have shown that higher ...
Weihua Zeng +2 more
exaly +2 more sources
Midkine characterization in human ovaries: potential new variants in follicles
F&S Science, 2023 Objective: To characterize the growth factor midkine (MDK) in the human ovary to determine whether MDK is produced locally within the ovary, examine whether different ovarian cell types are more likely to produce MDK, and determine whether there are any ...
Jesus Cadenas +2 more
exaly +2 more sources
Role of Midkine in Cancer Drug Resistance: Regulators of Its Expression and Its Molecular Targeting
International Journal of Molecular Sciences, 2023 Molecules involved in drug resistance can be targeted for better therapeutic efficacies. Research on midkine (MDK) has escalated in the last few decades, which affirms a positive correlation between disease progression and MDK expression in most cancers ...
Minakshi Saikia +2 more
exaly +3 more sources
Cancer Research, 2014
Abstract Lung cancer is the leading cause of cancer-related mortality worldwide. Although a platinum-doublet regimen has become the standard of care, the benefit is modest and the 5-year survival rate has remained essentially unchanged over the past 3 decades. Recently, several molecular alterations have been defined as “driver mutations,
Takuya Fukazawa +8 more
openaire +1 more source
Abstract Lung cancer is the leading cause of cancer-related mortality worldwide. Although a platinum-doublet regimen has become the standard of care, the benefit is modest and the 5-year survival rate has remained essentially unchanged over the past 3 decades. Recently, several molecular alterations have been defined as “driver mutations,
Takuya Fukazawa +8 more
openaire +1 more source
Genes to Cells, 1998
Background:Midkine (MK) is a growth factor implicated in the development and repair of various tissues, especially neural tissues. However, its in vivo function has not been clarified.Results:Knockout mice lacking the MK gene (Mdk) showed no gross abnormalities.
E, Nakamura +13 more
openaire +2 more sources
Background:Midkine (MK) is a growth factor implicated in the development and repair of various tissues, especially neural tissues. However, its in vivo function has not been clarified.Results:Knockout mice lacking the MK gene (Mdk) showed no gross abnormalities.
E, Nakamura +13 more
openaire +2 more sources
Inhibition of Midkine Suppresses Prostate Cancer CD133 + Stem Cell Growth and Migration
American Journal of the Medical Sciences, 2017 Background: Midkine (MDK) is a tumor-promoting factor that is often overexpressed in various human carcinomas, and the role of MDK has not yet been fully investigated in prostate cancer stem cells.
Suat Erdogan +2 more
exaly +1 more source