Preventing First and Further Decompensation in Advanced Chronic Liver Disease
ABSTRACT Advanced chronic liver disease (ACLD) remains a major cause of global morbidity and mortality. Preventing hepatic decompensation—both the first event and subsequent recurrences—has become a central therapeutic goal to prolong survival. The transition from the compensated phase (cACLD) to the decompensated phase (dACLD) is driven by clinically ...
Leonardo Corrêa Süffert +2 more
wiley +1 more source
Haemodynamic effects of fludrocortisone and midodrine in patients with symptoms due to hypotension [PDF]
Aim: The study aimed to assess the haemodynamic effects of fludrocortisone and midodrine, alone or combined, in patients with recurrent syncope and/or symptoms due to hypotension and ≥ 1 daytime systolic blood pressure (SBP) drop < 90 mmHg or ≥ 2 ...
van Zanten S. +12 more
core +1 more source
Blood Pressure and Early Mobilization After Total Hip and Knee Replacements A Pilot Study on the Impact of Midodrine Hydrochloride [PDF]
BACKGROUND: Early mobilization is an important therapeutic goal after total knee replacement and total hip replacement. Orthostatic hypotension and orthostatic intolerance can impede mobilization.
Lin, S +5 more
core +1 more source
SYNTHESIS OF DESGLYMIDODRINE FROM MIDODRINE BY CONVENTIONAL AMIDE HYDROLYSIS METHOD [PDF]
Objective: The term prodrug involves chemically modifying inert compound which upon administration releases the active parent drug to elicit its pharmacological response within the body.
S. N. Meyyanathan +7 more
core +2 more sources
Oral Midodrine Hydrochloride for Prevention of Orthostatic Hypotension during Early Mobilization after Hip Arthroplasty:A Randomized, Double-blind, Placebo-controlled Trial [PDF]
Background: Early postoperative mobilization is essential for rapid recovery but may be impaired by orthostatic intolerance (OI) and orthostatic hypotension (OH), which are highly prevalent after major surgery.
Mehlsen, J. +15 more
core +1 more source
Use of droxidopa for blood pressure augmentation after acute spinal cord injury: case reports [PDF]
Hypotension secondary to autonomic dysfunction is a common complication of acute spinal cord injury (SCI) that may worsen neurologic outcomes. Midodrine, an enteral α-1 agonist, is often used to facilitate weaning intravenous (IV) vasopressors, but its ...
Christopher S. Hong +11 more
doaj +1 more source
Movement Disorders Clinical Practice, Volume 13, Issue 5, Page 1326-1330, May 2026.
Jackson Mitzner +3 more
wiley +1 more source
Background Portal hypertension, which occurs as a consequence of liver cirrhosis, leads to splenic vasodilatation and alterations in the systemic circulation.
Hamdy M Moustafa +3 more
doaj +1 more source
HPLC Analysis of Midodrine and Desglymidodrine in Culture Medium: Evaluation of Static and Shaken Conditions on the Biotransformation by Fungi [PDF]
A high-performance liquid chromatography (HPLC) method is presented for the simultaneous determination of midodrine and desglymidodrine (DMAE) in Czapek-Dox culture medium, to be used in biotransformation studies by fungi. The HPLC analysis was conducted
González Collado, Isidro +4 more
core +1 more source

