Results 91 to 100 of about 44,246 (295)
Advanced Science, EarlyView.Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang +18 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang +15 more
wiley +1 more source
Sedimentary Mercury Enrichments as a Tracer of Large Igneous Province Volcanism
Geophysical Monograph Series, Page 247-262., 2021 Exploring the links between Large Igneous Provinces and dramatic environmental impact
An emerging consensus suggests that Large Igneous Provinces (LIPs) and Silicic LIPs (SLIPs) are a significant driver of dramatic global environmental and biological changes, including mass extinctions.
Lawrence M. E. Percival +3 more
wiley +3 more sources
MIF: Implications in the patho-aetiology of systemic lupus erythematosus
Frontiers in Immunology, 2015 Macrophage Migration Inhibitory factor (MIF) was one of the earliest pro-inflammatory cytokines to be identified. Increasing interest in this cytokine in recent decades has followed the cloning of human MIF and the generation of Mif-/- mice.
Tali eLang +4 more
doaj +1 more source
, 2009 Hirohito Kanemitsu, Mizuho Matsunawa, Kuninobu Wakabayashi, Michihito Sato, Ryo Takahashi, Tsuyoshi Odai, Takeo Isozaki, Nobuyuki Yajima, Yusuke Miwa, Tsuyoshi KasamaDivision of Rheumatology, Department of Medicine, Showa University School of Medicine ...
Hirohito Kanemitsu +4 more
core
Effect of hyperoxia on MIF expression in NB WT, MIF KO and MIF TG mice lungs at PN7.
, 2013 (A) Quantitative real-time PCR of MIF mRNA expression in lungs of NB mice exposed to hyperoxia (as described in “Methods” section) at PN7. Control lungs were exposed to room air for 7 days. The figure is representative of n = 3–4 mice per group.
Angara Sureshbabu (408164) +10 more
core +1 more source
Atypical Membrane-Anchored Cytokine MIF in a Marine Dinoflagellate
, 2020 International audienceMacrophage Migration Inhibitory Factors (MIF) are pivotal cytokines/chemokines for vertebrate immune systems. MIFs are typically soluble single-domain proteins that are conserved across plant, fungal, protist, and metazoan kingdoms,
Marro, Sophie +17 more
core +1 more source
Advanced Science, EarlyView.USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian +9 more
wiley +1 more source
Investigating the nuclease activity of MIF and MIF-2 and their effects on DNA damage [PDF]
The multifunctional inflammatory protein macrophage migration inhibitory factor (MIF) and its paralog D-dopachrome tautomerase (D-DT)/MIF-2 have important functions in various neurodegenerative diseases.
Bulut Impraim, Buket
core +1 more source
The upregulation of CD74, a chaperone involved in MHC-II antigen processing, has been mostly interpreted as indicative of antigen presentation in multiple brain disorders.
Diana Retana (355843) +80 more
core +1 more source