Results 81 to 90 of about 44,246 (295)

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

The Reality and Requirements of Developing the Islamic Banking Industry in Algeria ; a Case Study of Al Baraka Bank during the period 2008-2021

المجلة الدولية للأداء الاقتصادي
    This study aims to see the reality of the Islamic banking industry in Algeria, by shedding light on the reality of Islamic windows in traditional banks.
BENDJEBBES Yassamine
doaj  

Macrophage Migration Inhibitory Factor (MIF) Drives Murine Psoriasiform Dermatitis

Frontiers in Immunology, 2018
The immunomodulator Macrophage Migration Inhibitory Factor (MIF) exerts pleiotropic immunomodulatory activities and has been implicated in the pathogenesis of diverse inflammatory diseases.
Siegfried Bezdek, Lin Leng, Hauke Busch, Hauke Busch, Sadegh Mousavi, Dirk Rades, Markus Dahlke, Detlef Zillikens, Detlef Zillikens, Richard Bucala, Christian D. Sadik, Christian D. Sadik   +11 more
doaj   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

MIF Promotes Classical Activation and Conversion of Inflammatory Ly6Chigh Monocytes into TipDCs during Murine Toxoplasmosis

Mediators of Inflammation, 2016
Macrophage migration inhibitory factor (MIF) mediates immunity against Toxoplasma gondii infection by inducing inflammatory cytokines required to control the parasite replication.
Juan de Dios Ruiz-Rosado, Jonadab E. Olguín, Imelda Juárez-Avelar, Rafael Saavedra, Luis I. Terrazas, Frank H. Robledo-Avila, Alicia Vazquez-Mendoza, Jacquelina Fernández, Abhay R. Satoskar, Santiago Partida-Sánchez, Miriam Rodriguez-Sosa   +10 more
doaj   +1 more source

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

Advanced Science, EarlyView.
scGEN combines attribute–structure encoding, adaptive hard‐sample weighting, and regularized zero‐inflated negative binomial loss to resolve ambiguous single‐cell states. In the developing human pituitary, refined annotations reveal Pre.Gonado cells at 7 weeks and previously obscured developmental communication networks.
Fang Huang, Dayu Hu, Yaqi Dai, Aoyi Geng, Renxiang Guan, Hao Quan, Brett A. McGregor, Zhihan Wang, Nadeem Khan, Hongsheng Zhang, Jinghua Zhang, Mingyang Xia, Xiaoqiong Gu, Di Che, Junguk Hur, Xiaoyu Cui, Kai Guo   +16 more
wiley   +1 more source

Covert Optical Fingerprints Within Overt Structural Colors via Cascaded Cavity Resonances

Advanced Science, EarlyView.
Cascaded photonic–plasmonic cavities combine vivid structural colors with hidden stochastic optical fingerprints in a single monolithic platform. Layered cavities control the overt appearance, while disordered nanogap resonances generate covert scattering with limited mutual influence.
Gyurin Kim, Jiyeong Ma, Juhwan Kim, JuHyeong Lee, Heungchan Kwon, Young Min Song, Hyeon‐Ho Jeong   +6 more
wiley   +1 more source

MiRNA Regulation of MIF in SLE and Attenuation of Murine Lupus Nephritis With miR-654

Frontiers in Immunology, 2019
Objective: Macrophage Migration Inhibitory Factor (MIF) is involved in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). MicroRNAs (miRNAs) play important roles in LN but whether specific miRNAs regulate the expression of ...
Yang Tu, Ruru Guo, Jia Li, Suli Wang, Lin Leng, Jun Deng, Jun Deng, Richard Bucala, Liangjing Lu   +8 more
doaj   +1 more source

Association study of MIF promoter polymorphisms with suicide completers in the Japanese population

, 2017
Naofumi Shimmyo,1 Akitoyo Hishimoto,1 Ikuo Otsuka,1 Satoshi Okazaki,1 Shuken Boku,1 Kentaro Mouri,1 Tadasu Horai,1 Motonori Takahashi,2 Yasuhiro Ueno,2 Osamu Shirakawa,3 Ichiro Sora1 1Department of Psychiatry, 2Division of Legal Medicine, Department of ...
Boku S, Ueno Y, Shirakawa O, Sora I, Shimmyo N, Otsuka I, Horai T, Mouri K, Hishimoto A, Takahashi M, Okazaki S   +10 more
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