Results 71 to 80 of about 44,246 (295)

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Analysis of the role of Dirofilaria repens macrophage migration inhibitory factors in host–parasite interactions

Journal of Veterinary Research
Dirofilaria repens is a zoonotic parasitic filarial nematode that infects carnivores and occasionally humans. Knowledge of the host–parasite molecular interactions enabling the parasite’s avoidance of the host immune response in subcutaneous ...
Karabowicz Justyna, Długosz Ewa, Bąska Piotr, Pękacz Mateusz, Wysmołek Magdalena Elżbieta, Klockiewicz Maciej, Wiśniewski Marcin   +6 more
doaj   +1 more source

Digitaalisen oppimisen valmiuksien kartoittaminen kehittyvissä maissa [PDF]

, 2019
Työssä kartoitetaan tiettyjen kehittyvien maiden nykytilannetta internetin käytön ja koulutuksen suhteen. Tarkoituksena on selvittää, kuinka kyvykkäitä maiden asukkaat ovat digitaaliseen oppimiseen.
Pessi, Samuli
core  

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Antioxidant activity of Mif-1 and Tyr-Mif-1 in three models of stress [PDF]

, 2008
Address for correspondence: Assoc. Prof. Adriana Bocheva, Chair of Pathophysiology, Medical University, 2 Zdrave str., Bg – 1431 Sofia, е-mail: аdriana_bocheva@abv.bgПептидите от семейството на Tyr-MIF-1 – MIF-1 и Tyr-MIF-1, имат опиоидно и антиопиоидно ...
Бочева/Bocheva, A./A., Джамбазова/Dzhambazova, Е./E.   +1 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Uygur Halk Edebiyatının Milli Kimlik İnşasındaki Rolü Üzerine

Uluslararası Uygur Araştırmaları Dergisi, 2019
Milletlerin inşasında belirleyici etkenlerin birisi dildir. Dil bu süreçteki işlevini edebi eserlerle ifa eder. Okuma-yazma oranının düşük olduğu topluluklarda ise bu görevi sözlü kültür ürünleri yerine getirir.
Alimcan İNAYET
doaj  

The roles of macrophage migration inhibitory factor in retinal diseases

Neural Regeneration Research
Macrophage migration inhibitory factor (MIF), a multifunctional cytokine, is secreted by various cells and participates in inflammatory reactions, including innate and adaptive immunity. There are some evidences that MIF is involved in many vitreoretinal
Hongbing Zhang, Xianjiao Zhang, Hongsong Li, Bing Wang, Pei Chen, Jiamin Meng   +5 more
doaj   +1 more source