Results 51 to 60 of about 300,279 (264)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Exporting Poor Health: The Irish in England [PDF]
The Irish-born population in England is in worse health than both the native population and the Irish population in Ireland, a reversal of the commonly observed healthy migrant effect.
Alan Fernihough +2 more
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Russian Federation has experienced simultaneous declines in health and rises in international migration. Guided by the “healthy migrant effect†found elsewhere, we examine two questions. First, do the foreign-born in the Russian Federation exhibit
Cynthia Buckley +2 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Healthcare access for migrants in China : A new frontier [PDF]
How can healthcare access for Chinese migrants be improved? Migrant workers face two types of healthcare-access exclusion in the workplace: a financial one (via income) and a legislative one (from the "hukou").
Carine Milcent
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Society and health of migrants [PDF]
European Journal of Epidemiology, 2016 In London, in May 2016, a photograph was tweeted with the caption: “This is what a civilised society looks like”. The photo showed the inauguration of the newly elected London mayor—hardly remarkable in itself. But the specialness of the scene grows by degrees.
openaire +3 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Psychological Costs of Migration: Home Country Natural Disasters and Mental Health [PDF]
, 2020 The psychological toll of leaving one's familiar environment is a dominant explanation for why some people do not migrate despite relatively high wage differentials and low monetary costs of moving.
Bharadwaj, P. +3 more
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