Results 101 to 110 of about 3,438,934 (379)

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

Migration and Multiculturalism [PDF]

open access: yes, 2013
Abstract This chapter provides an overview of research on migration and multiculturalism from the perspective of political psychology. The first part outlines some historical benchmarks of modern migration and briefly presents two key notions of a psychological approach to migration—assimilation and multiculturalism—in their historical ...
Green, Eva G.T., Staerklé, Christian
openaire   +3 more sources

Dust Settling and Rapid Planetary Migration [PDF]

open access: yes, 2010
Planetary migration is essential to explain the observed mass-period relation for exoplanets. Without some stopping mechanism, the tidal, resonant interaction between planets and their gaseous disc generally causes the planets to migrate inward so efficiently that they plunge into the host star within the gaseous disc lifetime ($\sim $ 1-3 Myrs).
arxiv   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

open access: yesMolecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen   +6 more
wiley   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

Migration and Health: a fast Changing European Scenario

open access: yesEl Guiniguada, 2016
La migración está cambiando el desarrollo económico y demográfico de la Unión Europea y de los países de la Asociación del Mercado Libre Europeo y, desde la perspectiva de la salud, está afectando a la epidemiología de la enfermedad.
Manuel Carballo   +2 more
doaj  

Flight feather moult in Western Marsh Harriers during autumn migration

open access: yesAvian Research, 2019
Background Most of long-distance migratory raptors suspend moult during migration but detailed information is patchy for most of the Palearctic species.
Juan Ramírez, Michele Panuccio
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Systematic review of empiric studies on lockdowns, workplace closures, and other non-pharmaceutical interventions in non-healthcare workplaces during the initial year of the COVID-19 pandemic: benefits and selected unintended consequences

open access: yesBMC Public Health
Background We conducted a systematic review aimed to evaluate the effects of non-pharmaceutical interventions within non-healthcare workplaces and community-level workplace closures and lockdowns on COVID-19 morbidity and mortality, selected mental ...
Faruque Ahmed   +6 more
doaj   +1 more source

A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration [PDF]

open access: yes, 2014
Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.
Asuri, Prashanth   +2 more
core   +3 more sources

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