Results 51 to 60 of about 10,089 (262)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Monitoring of external migration processes as a tool of regional migration policy

Интеллект. Инновации. Инвестиции
The dual nature of the influence of international migration on the level of economic development, social situation and national security of the host country is considered.
L. V. Matraeva
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mechanisms for mitigating spatial heterogeneity of migration flows

Вестник университета
The mechanisms of smoothing the spatial heterogeneity of migration flows, which is one of the key issues of demography, regional economics, and public administration, have been studied.
A. A. Bychkova
doaj   +1 more source

External labor migration from Ukraine: causes, scale, consequences

European Journal of Management Issues, 2019
Purpose – to study the causes and consequences of migration processes. The results of the study. This article presents the results of an analysis of the dynamics and current state of labor migration processes in Ukraine.
Viktoria Apalkova, Anna Lyzunova
doaj   +1 more source

ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow

Blood, 2005
AbstractIn vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions (paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report that TEM is mostly paracellular. The mechanisms that control the route of leukocyte TEM remain unknown.
Lin, Yang, Richard M, Froio, Tracey E, Sciuto, Ann M, Dvorak, Ronen, Alon, Francis W, Luscinskas   +5 more
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Migration Policy of the European Union on the Countries of Northern Africa

Європейські історичні студії, 2019
The article is devoted to the actual issues of the European Union migration policy with regard to the countries of North Africa. Indeed, the intensive migration movement that has recently taken place in Europe has forced the EU to develop a new, adequate
Zinaida Sviashchenko
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ACTUALIZATION OF THE MIGRATION ACTIVITY MONITORING AT THE STATE LEVEL

RUDN Journal of Public Administration, 2015
Migration regulation belongs to the realm of the state government and inseparable component of the strategic interests of any country. Authors mention that migration is a process of the population changing its spatial location regardless of the causes ...
Evgeniya A Smirnova, Yury A Zubarev
doaj