Results 81 to 90 of about 2,446,659 (302)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment. [PDF]

PLoS Neglected Tropical Diseases, 2016
The dynamics of regulatory T cells in the course of Trypanosoma cruzi infection is still debated. We previously demonstrated that acute murine T. cruzi infection results in an impaired peripheral CD4+Foxp3+ T cell differentiation due to the acquisition ...
Florencia Belén González, Flavia Calmon-Hamaty, Synara Nô Seara Cordeiro, Rodrigo Fernández Bussy, Silvana Virginia Spinelli, Luciano D'Attilio, Oscar Bottasso, Wilson Savino, Vinícius Cotta-de-Almeida, Silvina Raquel Villar, Ana Rosa Pérez   +10 more
doaj   +1 more source

La pêche migrante au Sénégal, en Mauritanie et Gambie : un mécanisme d’approvisionnement des industries de farine de poisson

VertigO, 2023
The objective of the paper is to evaluate the quantitative contribution of the catches of migrant fishers to the supply of fish meal factories in Senegal, The Gambia and Mauritania. The method consisted first of identifying and quantifying the volumes of
El hadj Bara Dème, Pierre Failler
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Chapter Four. Chains Of Gold: Migratory Networks In Two Portuguese Immigrant Communities

, 2009
The 'chains of gold' displayed by migrants as proof of their success abroad that made such a long-lasting impression on Antonio also serve as a metaphor of the intricate network of family and village connections that created and sustained particular 'chains of migration' from the Algarve to Argentina.
openaire   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Extraction, Isolation, Structural Characterization and Anti-Tumor Properties of an Apigalacturonan-Rich Polysaccharide from the Sea Grass Zostera caespitosa Miki

Marine Drugs, 2015
An apigalacturonan (AGA)-rich polysaccharide, ZCMP, was isolated from the sea grass Zostera caespitosa Miki. The depolymerized fragments derived from ZCMP were obtained by either acidic degradation or pectinase degradation, and their structures were ...
Youjing Lv, Xindi Shan, Xia Zhao, Chao Cai, Xiaoliang Zhao, Yinzhi Lang, He Zhu, Guangli Yu   +7 more
doaj   +1 more source

MiR-146a-5p deficiency in extracellular vesicles of glioma-associated macrophages promotes epithelial-mesenchymal transition through the NF-κB signaling pathway

Cell Death Discovery, 2023
Glioma-associated macrophages (GAMs) are pivotal chains in the tumor immune microenvironment (TIME). GAMs mostly display M2-like phenotypes with anti-inflammatory features related to the malignancy and progression of cancers.
Chao Xu, Pan Wang, Haiyan Guo, Chuan Shao, Bin Liao, Sheng Gong, Yanghao Zhou, Bingjie Yang, Haotian Jiang, Gang Zhang, Nan Wu   +10 more
doaj   +1 more source

Ocean Energy: Using the Ocean's Tides, Waves, and Heat to Generate Electricity [PDF]

, 2006
Key facts: - The oceans' tides, waves, current, and heat can be used to generate electricity. These resources are renewable, because the moon's gravity drives tides, and winds create waves.

core  

Multiple Roles for Slits in the Control of Cell Migration in the Rostral Migratory Stream

Journal of Neuroscience, 2004
The subventricular zone (SVZ) contains undifferentiated cells, which proliferate and generate olfactory bulb (OB) interneurons. Throughout life, these cells leave the SVZ and migrate along the rostral migratory stream (RMS) to the OB where they ...
K. Nguyen-Ba-Charvet, N. Picard-Riéra, M. Tessier-Lavigne, A. Baron-Van Evercooren, C. Sotelo, A. Chédotal   +5 more
semanticscholar   +1 more source