Results 1 to 10 of about 17,026 (178)

Design, Optimization, Manufacture and Characterization of Milbemycin Oxime Nanoemulsions [PDF]

Pharmaceutics
Background: Despite the rapid development of nanoemulsions in recent years, no method has been established for the preparation of milbemycin oxime nanoemulsions.
Fan Yang, Ming-Hui Duan, Yang-Guang Jin
exaly   +7 more sources

Pharmacokinetics of Milbemycin Oxime in Pekingese Dogs After Single Oral and Intravenous Administration [PDF]

Veterinary Medicine and Science
Objective This study aimed to characterize the pharmacokinetic profiles of milbemycin oxime in Pekingese dogs following a single oral (PO) and intravenous (IV) dose. Six clinically healthy Pekingese dogs, with an average body weight (BW) of 4.75 kg, were
Xing-Ping Li, Ming-Hui Duan, Yang-Guang Jin   +2 more
exaly   +6 more sources

Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) for the prevention of heartworm disease (Dirofilaria immitis) in client-owned dogs in the USA [PDF]

Parasites & Vectors, 2021
Background Dirofilaria immitis, a globally distributed filarial parasite of dogs, is known to cause serious or fatal cardiopulmonary disease. Client-owned dogs were enrolled in a clinical field study in the USA to evaluate the clinical effectiveness and ...
Lisa M. Young, Scott Wiseman, Elizabeth Crawley, Kim Wallace, Daniel E. Snyder   +4 more
doaj   +2 more sources

Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) against natural intestinal nematode infections in dogs presented as veterinary patients in Europe [PDF]

Parasites & Vectors, 2021
Background A randomised, blinded, positive controlled, multicentre, Good Clinical Practice-compliant, pivotal field study was conducted to evaluate the effectiveness and safety of a new combination of lotilaner + milbemycin oxime tablets (Credelio® Plus;
Brad Hayes, Scott Wiseman, Daniel E. Snyder   +2 more
doaj   +2 more sources

Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) against natural flea and tick infestations on dogs presented as veterinary patients in Europe [PDF]

Parasites & Vectors, 2021
Background A pivotal randomised, blinded, positive-controlled, multicentre, European field study was conducted to evaluate the effectiveness and safety of a novel combination tablet of lotilaner and milbemycin oxime (Credelio® Plus) administered orally ...
Sophie Forster, Scott Wiseman, Daniel E. Snyder   +2 more
doaj   +2 more sources

Effectiveness of Credelio® Plus, a novel chewable tablet containing milbemycin oxime and lotilaner for the treatment of larval and immature adult stages of Toxocara canis in experimentally infected dogs [PDF]

Parasites & Vectors, 2021
Background The ascarid, Toxocara canis, is a common and important zoonotic intestinal nematode parasite that infects dogs globally. An effective treatment that kills any pre-patent stages of immature T.
Lisa M. Young, Scott Wiseman, Elizabeth Crawley, Dwight D. Bowman, Craig R. Reinemeyer, Daniel E. Snyder   +5 more
doaj   +2 more sources

Effectiveness of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) for the treatment of larval and immature adult stages of Ancylostoma caninum in experimentally infected dogs [PDF]

Parasites & Vectors, 2021
Background The hookworm, Ancylostoma caninum, is a common and important zoonotic intestinal nematode parasite that infects dogs globally. Both the immature and adult stages of A.
Daniel E. Snyder, Scott Wiseman, Elizabeth Crawley, Kim Wallace, Dwight D. Bowman, Craig R. Reinemeyer   +5 more
doaj   +2 more sources

Development and validation of an LC–MS/MS method for the simultaneous quantification of milbemycin oxime and praziquantel in plasma: application to a pharmacokinetic study in cats [PDF]

Frontiers in Veterinary Science, 2023
IntroductionMilbemycin oxime (MBO) and praziquantel (PZQ) have a broad spectrum of biological activity and are commonly used to treat the parasitic infection in the veterinary clinic.
Shiting Xie, Shiting Xie, Yixing Lu, Yixing Lu, Jun Wang, Jun Wang, Changcheng Lin, Changcheng Lin, Peiyu Ye, Peiyu Ye, Xiaolin Liu, Wenguang Xiong, Wenguang Xiong, Zhenling Zeng, Zhenling Zeng, Dongping Zeng, Dongping Zeng   +16 more
doaj   +2 more sources

Efficacy of milbemycin oxime/afoxolaner chewable tablets (NEXGARD SPECTRA®) against Capillaria aerophila and Capillaria boehmi in naturally infected dogs [PDF]

Parasites & Vectors, 2021
Background Capillaria aerophila and Capillaria boehmi parasitize the respiratory system of wild and domestic carnivores. Capillaria aerophila inhabits the trachea and bronchi of dogs and cats, while C.
Angela Di Cesare, Simone Morelli, Giulia Morganti, Giulia Simonato, Fabrizia Veronesi, Mariasole Colombo, Michele Berlanda, Wilfried Lebon, Matilde Gallo, Frederic Beugnet, Donato Traversa   +10 more
doaj   +2 more sources

Long-term and acute safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) in juvenile and adult dogs [PDF]

Parasites & Vectors, 2021
Background The combination of milbemycin oxime (MO) and lotilaner (Credelio® Plus) is a novel systemic endectocide that provides month-long effectiveness in dogs after a single oral treatment.
Kari L. Riggs, Scott Wiseman
doaj   +2 more sources