Results 91 to 100 of about 17,026 (178)

Biotransformation of milbemycin D to milbemycin G by Streptomyces lividans conferring avermectin O-methyltransferase activity

, 1998
Avermectin O-methyltransferase gene was cloned from a cosmid clone covering the first module of polyketide synthase gene cluster of avermectin biosynthesis.
Kyu Won Kim, Bang Yeon Hwang, Young Soo Hong, Jeong Hyung Lee, Hang Sub Kim, Jung Joon Lee, Kyu-Won Kim, Young-Soo Hong, Jeong-hyung Lee   +8 more
core   +1 more source

In vitro effects of milbemycin oxime: mechanism of action againstAngiostrongylus cantonensis andDirofilaria immitis

Parasitology Research, 1992
The neuropharmacological mechanisms underlying the action of milbemycin oxime on the motility of Angiostrongylus cantonensis and Dirofilaria immitis were examined in vitro. In A. cantonensis, milbemycin oxime caused inhibitory effects at low concentrations of > or = 10(-9) g/ml, and paralysis was elicited at 10(-8) - 10(-6) g/ml.
H H, Lee, M, Terada
openaire   +2 more sources

Detection of Dirofilaria repens microfilariae in dog’s blood samples and an oral milbemycin oxime/praziquantel formulation efficacy evaluation in the X small animal clinic [PDF]

, 2017
Dirofilaria repens is one of the most widespread mosquito borne filarioid which causes cutaneous dirofilariasis in dogs. Cats and other mammals, humans among them, can also be infected.
Saukienė, Kotryna
core  

Analysis of an eligible protocol for bioequivalence testing of two Canine anthelmintics products with two active molecules

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine
This study is intended to analyze the design implemented in the bioequivalence testing of a generic product based on praziquantel and milbemycin oxime. The main objective of the study is to develop a protocol suitable for testing the bioequivalence and ...
Diana Denisa TODORAN, Melania CRIȘAN, Octavia TAMAS-KRUMPE, Daria FENESAN, Doru NECULA, Laurențiu OGNEAN   +5 more
doaj   +1 more source

Shifting the paradigm in Dirofilaria immitis prevention: blocking transmission from mosquitoes to dogs using repellents/insecticides and macrocyclic lactone prevention as part of a multimodal approach

Parasites & Vectors, 2017
Background This study assessed the influence of a topical ectoparasiticide (dinotefuran-permethrin-pyriproxyfen, DPP, Vectra® 3D, Ceva Animal Health) combined with a macrocyclic lactone (milbemycin oxime, MBO, Interceptor®, Virbac) on transmission of ...
John W. McCall, Marie Varloud, Elizabeth Hodgkins, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, James Carmichael, Ben Carson, Justin Carter   +8 more
doaj   +1 more source

Preference of Dogs between Two Oral Formulations of Endectoparasiticides: NEXGARD SPECTRA ® (Afoxolaner and Milbemycin Oxime) and Simparica Trio TM (Sarolaner, Moxidectin and Pyrantel) Preference of Dogs between Two Oral Formulations of Endectoparasiticides: NEXGARD SPECTRA (Afoxolaner and Milbemycin Oxime) and Simparica Trio TM

, 2020
International audiencePet owner compliance is essential for the success of veterinary healthcare strategies. As some parasites are zoonotic, consistent parasite control is an integral part of the One-Health strategy.
Chalvet-Monfray, Karine, Gross, Sheila, Everett, William Russel, Perier, Nadège, Wongnak, Phrutsamon, Beugnet, Frédéric, Carithers, Douglas   +6 more
core   +1 more source

Treatment of canine sarcoptic mange with afoxolaner (NexGard®) and afoxolaner plus milbemycin oxime (NexGard Spectra®) chewable tablets: efficacy under field conditions in Portugal and Germany

Parasite, 2018
The efficacy of NexGard® and NexGard Spectra® against sarcoptic mange in dogs was evaluated in a clinical field study. Skin scrapings from dogs presenting signs suggestive of sarcoptic mange were examined to confirm infestation.
Hampel Verena, Knaus Martin, Schäfer Jürgen, Beugnet Frederic, Rehbein Steffen   +4 more
doaj   +1 more source

Safety of oral afoxolaner formulated with or without milbemycin oxime in homozygous MDR1-deficient collie dogs. [PDF]

J Vet Pharmacol Ther, 2022
Drag M, Tielemans E, Mitchell E.
europepmc   +1 more source

Synthesis and Immunological Evaluation of Virus-Like Particle-Milbemycin A3/A4 Conjugates

, 2017
Milbemycins are macrolide antibiotics with a broad spectrum of nematocidal, insecticidal, and acaricidal activity. To obtain milbemycin A3/A4 derivatives suitable for chemical conjugation to protein carriers (milbemycin haptens), succinate linker and a ...
Ieva Kalnciema, Māris Turks, Ērika Bizdēna, Dace Skrastina, Jevgeņija Lugiņina, Andris Zeltins, Vitalijs Skrivelis, Ina Balke   +7 more
core   +1 more source

Development and Validation of the Multi-Residue Method for Identification and Quantitation of Six Macrolide Antiparasitic Drugs

Applied Sciences
Objective: This study aimed to develop a robust multi-residue analytical method for the precise identification and quantification of six macrolide antiparasitic agents commonly used in animal husbandry feeds.
Chuanmin Cheng, Yannan Chen, Xinyu Liu, Yanmin Lei, Qianxi Qin, Linli Cheng   +5 more
doaj   +1 more source