Results 141 to 150 of about 542,808 (329)

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

Mild cognitive impairment: a concept in evolution

Journal of Internal Medicine, 2014
R. Petersen, B. Caracciolo, B. Caracciolo, C. Brayne, S. Gauthier, V. Jelic, L. Fratiglioni   +6 more
semanticscholar   +1 more source

A Systematic Computational Framework for Practical Identifiability Analysis in Mathematical Models Arising from Biology

Advanced Science, EarlyView.
A systematic computational framework is developed for practical identifiability analysis in biological models. The framework establishes a rigorous definition, introduces efficient coordinate‐based identifiability metrics, and proposes novel regularization strategies.
Shun Wang, Wenrui Hao
wiley   +1 more source

From mild cognitive impairment to subjective cognitive decline: conceptual and methodological evolution

Neuropsychiatric Disease and Treatment, 2017
Yu-Wen Cheng,1 Ta-Fu Chen,2 Ming-Jang Chiu2,3 1Department of Neurology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan; 2Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan ...
Cheng YW, Chen TF, Chiu MJ
doaj  

Medial temporal lobe function and structure in mild cognitive impairment [PDF]

, 2004
Bradford C. Dickerson, David H. Salat, Julianna F. Bates, M. Atiya, Ronald Killiany, Douglas N. Greve, Anders M. Dale, Chantal E. Stern, Deborah Blacker, Marilyn Albert, Reisa A. Sperling   +10 more
openalex   +1 more source

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

Advanced Science, EarlyView.
This study introduces a novel, safe, and effective surgical technique: Cranial bone transport (CBT) to improve traumatic brain injury (TBI) outcomes in rats. CBT significantly accelerated skull defect bone repair in addition to its promoting effects on neurological function recovery. This work provides an alternative therapy for patients suffering from
Shanshan Bai, Xuan Lu, Xu Yan, Han Su, Yuejun Lin, Zhaowei Jiang, Zhixian Zong, Haixing Wang, Leo Yik Chun Yan, Xiaoting Zhang, Ming Wang, Zhengmeng Yang, Jiakang Jin, Yaofeng Wang, Wayne Yuk‐Wai Lee, Xiaohua Jiang, Ho Ko, Lu Feng, Micky D. Tortorella, Sien Lin, Gang Li   +20 more
wiley   +1 more source

Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment [PDF]

, 2004
Thomas Koenig, Leslie S. Prichep, Thomas Dierks, Daniela Hubl, Lars‐Olof Wahlund, E. Roy John, Vesna Jelić   +6 more
openalex   +1 more source

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

Advanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu, Nan Li, Yi‐Wen Lv, Wen‐Miao Yang, Zhi‐Yun Yu, Yi‐Min Zhang, Yu Guo, Xiao‐Yin Chen   +7 more
wiley   +1 more source

Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study [PDF]

, 2004
Tiia Anttila, Eeva‐Liisa Helkala, Matti Viitanen, Ingemar Kåreholt, Laura Fratiglioni, Bengt Winblad, Hilkka Soininen, Jaakko Tuomilehto, Aulikki Nissinen, Miia Kivipelto   +9 more
openalex   +1 more source

Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?

Advanced Science, EarlyView.
Despite advancements in implantable electrode technology, challenges persist in scaling up these devices to record most of the neuronal activity across the cortex. This review explores the limitations of both rigid and flexible probes, including tissue damage and foreign body response, while also discussing emerging biohybrid strategies.
Attila Kaszás, Domokos Meszéna, Richárd Fiáth, Andrea Slézia, István Ulbert, Gergely Katona   +5 more
wiley   +1 more source