Results 161 to 170 of about 284,848 (306)

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment. [PDF]

Brain Behav
Hu J, Lei P, Zhang J, Wu Q, Zhang Z, Zhu X, Li B.   +6 more
europepmc   +1 more source

Low uric acid is a risk factor in mild cognitive impairment

, 2017
LingLing Xue, YongBing Liu, HuiPing Xue, Jin Xue, KaiXuan Sun, LinFeng Wu, Ping Hou School of Nursing, YangZhou University, Yangzhou City, China Background: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and ...
Liu Y, Wu L, Hou P, Xue L, Xue J, Xue H, Sun K   +6 more
core  

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

A sensorimotor function construct to assess mild cognitive impairment risk. [PDF]

Alzheimers Dement
Wanigatunga AA, Wang H, Huang D, Davoudi A, Dougherty RJ, Tian Q, Deal JA, Abraham AG, Simonsick EM, Gross AL, Resnick SM, Ferrucci L, Schrack JA.   +12 more
europepmc   +1 more source

Deficits in retrospective and prospective components underlying prospective memory tasks in amnestic mild cognitive impairment

, 2012
Objectives: By use of purer indices of PM and RM components than previous studies and adoption of three PM task types, the present study aimed to investigate the deficits of these two components underlying global impairment at a PM task in individuals ...
Li, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, 4A Datun Rd, Beijing 100101, Peoples R China., Li, Juan, Zhou, Ting, Broster, Lucas S., Wang, Huali, Jiang, Yang, Bao, Feng   +6 more
core  

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

Advanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang, Changwen Yang, Qian Yao, Xuewei Du, Shuai Ding, Yaoqiang Shi, Can Sheng, Ming Wang, Ying Han, Haiming Luo   +9 more
wiley   +1 more source

Orthostatic intolerance predicts mild cognitive impairment: incidence of mild cognitive impairment and dementia from the Swedish general population cohort Good Aging in Skåne

, 2014
Sölve Elmståhl, Elisabet Widerström Division of Geriatric Medicine, Department of Health Sciences, Lund University, Skåne University Hospital, Malmö, Sweden Introduction: Contradictory results have been reported on the ...
Elmståhl S, Widerström E
core  

Short‐Term Outcomes and Cost Drivers of Emergency Surgery for Acute Abdominal Disease in Super‐Elderly Patients: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study analyzed patients aged ≥ 85 years undergoing emergency abdominal surgery, focusing on short‐term outcomes and inpatient cost structure under the Japanese DPC system. Although major complications occurred in 19.4% of patients, more than 70% were discharged home.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shojiro Hata, Hirokazu Yamaguchi   +8 more
wiley   +1 more source

Emotional-cognitive integration in aging: the role of alexithymia in mild cognitive impairment. [PDF]

Front Public Health
Marselli G, Corbo I, Pecchinenda A, Forte G, Favieri F, Troisi G, Blasutto B, Casagrande M.   +7 more
europepmc   +1 more source