Results 41 to 50 of about 542,808 (329)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Iñigo Ruíz‐Barrio, Javier Pagonabarraga, Anna Vázquez‐Oliver, Andrea Horta‐Barba, Jaime Kulisevsky, Saül Martínez‐Horta   +7 more
wiley   +1 more source

Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial

Alzheimer’s Research & Therapy, 2022
Introduction Basic studies suggest that olfactory dysfunction and functional near-infrared spectroscopy (fNIRS) can be used as tools for the diagnosis of mild cognitive impairment (MCI); however, real-world evidence is lacking.
Jaewon Kim, Dong Keon Yon, Kyu Yeong Choi, Jang Jae Lee, Namwoo Kim, Kun Ho Lee, Jae Gwan Kim   +6 more
doaj   +1 more source

Precision‐Optimised Post‐Stroke Prognoses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Current medicine cannot confidently predict who will recover from post‐stroke impairments. Researchers have sought to bridge this gap by treating the post‐stroke prognostic problem as a machine learning problem, reporting prediction error metrics across samples of patients whose outcomes are known.
Thomas M. H. Hope, Howard Bowman, Rachel M. Bruce, Alex P. Leff, Cathy J. Price   +4 more
wiley   +1 more source

Validation of Addenbrooke’s cognitive examination III for detecting mild cognitive impairment and dementia in Japan

BMC Geriatrics, 2019
Background Early detection of mild cognitive impairment (MCI) and dementia is very important to begin appropriate treatment promptly and to prevent disease exacerbation.
Shintaro Takenoshita, Seishi Terada, Hidenori Yoshida, Megumi Yamaguchi, Mayumi Yabe, Nao Imai, Makiko Horiuchi, Tomoko Miki, Osamu Yokota, Norihito Yamada   +9 more
doaj   +1 more source

Pulse Pressure, White Matter Hyperintensities, and Cognition: Mediating Effects Across the Adult Lifespan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate whether pulse pressure or mean arterial pressure mediates the relationship between age and white matter hyperintensity load and to examine the mediating effect of white matter hyperintensities on cognition. Methods Demographic information, blood pressure, current medication lists, and Montreal Cognitive Assessment ...
Jade Hannan, Sarah Newman‐Norlund, Natalie Busby, Sarah C. Wilson, Roger Newman‐Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha, Nicholas Riccardi   +8 more
wiley   +1 more source

The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease

Brain Sciences
Background/Objectives: Mild behavioral impairment (MBI) is an early marker of Alzheimer’s disease (AD) and other neurodegenerative diseases, often preceding cognitive decline. The MBI Checklist (MBI-C) is a 34-item tool designed to detect MBI. This study
Efthalia Angelopoulou, Evangelia Stanitsa, Maria Hatzopoulou, Akylina Despoti, Niki Tsinia, Vasiliki Kamtsadeli, Marina Papadogiani, Vasilis Kyriakidis, Sokratis Papageorgiou, John D. Papatriantafyllou   +9 more
doaj   +1 more source

Application of Deep Learning in Classification and Diagnosis of Mild Cognitive Impairment [PDF]

Jisuanji kexue yu tansuo
Alzheimer's disease is an irreversible neurodegenerative disease that has not been completely cured, but its progression can be delayed by early intervention. Mild cognitive impairment is the initial stage of Alzheimer??s disease.
ZHOU Qixiang, WANG Xiaoyan, ZHANG Wenkai, HE Xin
doaj   +1 more source

State of the science on mild cognitive impairment (MCI)

CNS Spectrums, 2019
Mild cognitive impairment (MCI) represents a transitional stage between healthy aging and dementia, and affects 10–15% of the population over the age of 65.
N. Anderson
semanticscholar   +1 more source