Results 41 to 50 of about 474,198 (345)

Permutation entropy and irreversibility in gait kinematic time series from patients with mild cognitive decline and early alzheimer’s dementia [PDF]

, 2019
Gait is a basic cognitive purposeful action that has been shown to be altered in late stages of neurodegenerative dementias. Nevertheless, alterations are less clear in mild forms of dementia, and the potential use of gait analysis as a biomarker of ...
Algarra Lucas, María del Carmen, Chicalna Actis, Guadalupe, Fernández Travieso, Jorge, Gómez Andrés, David, Martin Gonzalo, Juan Andrés, Miralles Martínez, Ambrosio A., Palmí Cartés, Itziar, Pulido Valdeolivas, Irene, Rausell, Estrella, Torrecillas Narváez, María Dolores, Wang, Ting, Wang, Yu, Zanin, Massimiliano   +12 more
core   +2 more sources

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Souvenaid in the Management of Mild Cognitive Impairment: An Expert Consensus Opinion [PDF]

, 2019
Background Mild cognitive impairment (MCI) among an aging global population is a growing challenge for healthcare providers and payers. In many cases, MCI is an ominous portent for dementia.
Bertolucci, Paulo, Cappa, Stefano, Chen, Christopher, Chu, Leung-Wing, Cummings, Jeffrey, Engelborghs, Sebastiaan, Garcia-Ribas, Guillermo, Manzano, Sagrario, McGuinness, Bernadette, Mok, Vincent, Passmore, Peter, Woodward, Michael   +11 more
core   +3 more sources

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Bibliometric analysis of papers on mild cognitive impairment nursing in China

International Journal of Nursing Sciences, 2017
Purpose: To supply further references by analyzing the status of research on mild cognitive impairment nursing in China. Methods: Papers on mild cognitive impairment nursing published between 2005 and 2014 were collected from China National Knowledge ...
Yating Ai, Kaili Sun, Hui Hu
doaj   +1 more source

Amyloid positron emission tomography candidates may focus more on benefits than risks of results disclosure [PDF]

, 2018
IntroductionGiven mounting calls to disclose biomarker test results to research participants, we explored factors underlying decisions by patients with mild cognitive impairment to receive amyloid imaging results.MethodsProspective, qualitative ...
Hu, Lu, Kim, Hyejin, Lingler, Jennifer H, Lopez, Oscar L, Mattos, Meghan, McDade, Eric, Morris, Jonna L, Rorberts, J. Scott   +7 more
core   +2 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Mild Cognitive Impairment: the Manchester consensus [PDF]

Age and Ageing, 2020
AbstractGiven considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild cognitive impairment (MCI).
Dunne, RA, Aarsland, D, O'Brien, JT, Ballard, C, Bannerjee, S, Fox, NC, Isaacs, JD, Underwood, BR, Perry, RJ, Chan, D, Dening, T, Thomas, AJ, Schryer, J, Jones, A-M, Evans, AR, Alessi, C, Coulthard, EJ, Pickett, J, Elton, P, Jones, RW, Mitchell, S, Graham, S, Hooper, N, Kalafatis, C, Rasmussen, JGC, Martin, H, Schott, JM, Burns, A   +27 more
openaire   +8 more sources

Mild cognitive impairment and dementia in a heterogeneous elderly population: prevalence and risk profile [PDF]

, 2013
OBJECTIVE: To describe the demographic, clinical and risk profile of Mild Cognitive Impairment and dementia in a sample of elderly South Africans within a residential setting.
Bhigjee, Ahmed, Chipps, Jennifer, Pillay, Basil, Ramlall, Suvira   +3 more
core   +2 more sources