Results 61 to 70 of about 284,848 (306)

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Relationships between Serum Lipid, Uric Acid Levels and Mild Cognitive Impairment in Parkinson's Disease and Multiple System Atrophy

Journal of Integrative Neuroscience
Background: Mild cognitive impairment is one of the non-motor symptoms in Parkinson's disease (PD) and multiple system atrophy (MSA). Few studies have previously been conducted on the correlation between serum uric acid (SUA) and lipid
Xiaoqiao Ren, Pan Wang, Hao Wu, Shuai Liu, Jinhong Zhang, Xiyu Li, Yong Ji, Zhihong Shi   +7 more
doaj   +1 more source

Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease

, 2010
The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail.
Bartley, Máiréad, Lamberton, Franck, O'Neill, Des, D Rónán Collins, David Prvulovic, O'Dwyer, Laurence, D. Rónán Collins, Collins, D Rónán, Máiréad Bartley, Faluyi, Yetunde O., Harald Hampel, Bokde, Arun L. W., Mazoyer, Bernard M., Mazoyer, Bernard, Yetunde O. Faluyi, Hampel, Harald, Bokde, Arun L W, Laurence O'Dwyer, Arun L. W. Bokde, Prvulovic, David, Michael Ewers, Ewers, Michael, Faluyi, Yetunde O, Colby Tanner, Tanner, Colby, Franck Lamberton, Collins, D. Rónán, Coughlan, Tara, Des O'Neill, Arun L W Bokde, Yetunde O Faluyi, Bernard Mazoyer, Tara Coughlan   +32 more
core   +1 more source

Sensitive Measures of Cognition in Mild Cognitive Impairment

Journal of Alzheimer's Disease, 2020
Background: Sensitive measures of cognition are needed in preclinical and prodromal Alzheimer’s disease (AD) to track cognitive change and evaluate potential interventions. Neurofibrillary tangle pathology in AD is first observed in Brodmann Area 35 (BA35), the medial portion of the perirhinal cortex.
Nathaniel Klooster, Stacey Humphries, Eileen R. Cardillo, Franziska Hartung, Long Xie, Sandhitsu Das, Paul Yushkevich, Arun Pilania, Jieqiong Wang, David Wolk, Anjan Chatterjee   +10 more
openaire   +4 more sources

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Perceived experiences of adults with mild cognitive impairment: a qualitative study

BMC Psychology
Introduction Increasing attention is being paid to preventing the progression of mild cognitive impairment and dementia. Today, there is a growing emphasis on listening to the “voice” of people with mild cognitive impairment to ensure patient-centered ...
Poursoleiman Leila, Rooddehghan Zahra, Bahramnezhad Fatemeh, Shafiee Sabet Mahdi, Dehghan Nayeri Nahid   +4 more
doaj   +1 more source

The Greek Version of the Mild Behavioral Impairment Checklist (MBI-C): Psychometric Properties in Mild Cognitive Impairment Due to Alzheimer’s Disease

Brain Sciences
Background/Objectives: Mild behavioral impairment (MBI) is an early marker of Alzheimer’s disease (AD) and other neurodegenerative diseases, often preceding cognitive decline. The MBI Checklist (MBI-C) is a 34-item tool designed to detect MBI. This study
Efthalia Angelopoulou, Evangelia Stanitsa, Maria Hatzopoulou, Akylina Despoti, Niki Tsinia, Vasiliki Kamtsadeli, Marina Papadogiani, Vasilis Kyriakidis, Sokratis Papageorgiou, John D. Papatriantafyllou   +9 more
doaj   +1 more source

Cognitive and behavioral impairment in mild hyperphenylalaninemia [PDF]

The Turkish Journal of Pediatrics, 2018
As elevated phenylalanine (Phe) is detrimental to brain functions, determining a safe upper limit of blood Phe is important for initiation of treatment plans and setting Phe targets in hyperphenlalaninemic patients. It is accepted that Phe levels below 360 μmol/L does not impair brain function and hence does not require treatment.
Evinc, S. Gulin, Pektas, Emine, Foto-Ozdemir, Dilsad, Yildiz, Yilmaz, Karaboncuk, Yamac, Bilginer-Gurbuz, Berrak, Dursun, Ali, Tokatli, Aysegul, Coskun, Turgay, Oktem, Ferhunde, Sivri, H. Serap   +10 more
openaire   +4 more sources

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Preventing disability in older adults with mild cognitive impairment: A Strategy Training intervention study

Contemporary Clinical Trials Communications, 2019
Non-pharmacological interventions designed to change cognitive function in older adults with Mild Cognitive Impairment have shown mixed results. Few studied interventions directly address preclinical disability. Slowing changes in disability are critical
Juleen Rodakowski, Katlyn W. Golias, Charles F. Reynolds, III, Meryl A. Butters, Oscar L. Lopez, Mary Amanda Dew, Elizabeth R. Skidmore   +6 more
doaj   +1 more source