Results 41 to 50 of about 2,881,091 (302)

Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration. [PDF]

, 2013
OBJECTIVE: To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD).
Manning, Emily N, Manning, EN, Leung, Kelvin K, Leung, Kelvin K., Bartlett, Jonathan W., Fox, Nick C, Fox, Nick C., Barnes, Josephine, Ourselin, Sebastien, Alzheimer's Disease Neuroimaging Initiative, Bartlett, Jonathan W, Bartlett, JW, Ourselin, S, Fox, NC, Manning, Emily N., Barnes, J, Leung, KK   +16 more
core   +1 more source

Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer’s disease

Journal of Integrative Neuroscience, 2021
Cerebrospinal fluid neurofilament light and plasma neurofilament light concentrations are elevated in patients with mild cognitive impairment and Alzheimer’s disease.
Yi Chen, Joseph Therriault, Jing Luo, Maowen Ba, Hua Zhang, Alzheimer’s Disease Neuroimaging Initiative   +5 more
doaj   +1 more source

Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study. [PDF]

, 2013
Cerebral small vessel disease (SVD) is a common cause of vascular cognitive impairment. A number of disease features can be assessed on MRI including lacunar infarcts, T2 lesion volume, brain atrophy, and cerebral microbleeds.
Lawrence, AJ, Barrick, Thomas R., Lawrence Andrew J., Barrick Thomas R., Andrew J Lawrence, Robin G Morris, MacKinnon, Andrew D., Hugh S. Markus, Thomas R Barrick, Bhavini Patel, Robin G. Morris, MacKinnon, AD, Bhavini Patel (405150), Barrick, TR, Philip M. Rich (405153), Markus, HS, Andrew D. MacKinnon, Rich, PM, Thomas R. Barrick (405154), Thomas R. Barrick, Hugh S Markus, Lawrence, Andrew J.; id_orcid, Patel, B, Andrew J. Lawrence, MacKinnon Andrew D., Rich, Philip M., Hugh S. Markus (366687), Andrew J. Lawrence (292444), Robin G. Morris (405151), Morris, RG, Patel Bhavini, Morris Robin G., Morris, Robin G., Andrew D MacKinnon, Rich Philip M., Patel, Bhavini, Philip M Rich, Andrew D. MacKinnon (405152), Markus Hugh S., Philip M. Rich, Markus, Hugh S.   +40 more
core   +2 more sources

Differences between memoryencoding and retrieval failure in mild cognitive impairment: results from quantitative electroencephalography and magnetic resonance volumetry [PDF]

, 2021
Background The memory impairments in mild cognitive impairment (MCI) can be classified into encoding (EF) and retrieval (RF) failure, which can be affected by underlying pathomechanism.
Kang, Dong W, Youn, Young C, Han, Su-Hyun, Jeong, Ho T, Yeo, Soeun, Kim, SangYun, Pyun, Jung-Min, Kang, Seung W   +7 more
core   +1 more source

Effect of 3-month exercise and soy peptide intake on mild cognitive impairment: semi-randomized controlled trial [PDF]

, 2022
Soy peptide, when consumed as a functional food, has been reported to improve cognitive function. The combined effects of soy peptide intake and exercise on cognitive function have been demonstrated.
Masahisa IBUKI, Masatoshi TAKEDA, Ryota IMAI, Mitsumasa HIDA, Fumie TAZAKI, Hidetoshi NAKAO, Masakazu IMAOKA, Misa NAKAMURA, Motohiro MAEBUCHI   +8 more
core   +1 more source

Longitudinal changes in task-evoked brain responses in Parkinson’s disease patients with and without mild cognitive impairment

Frontiers in Neuroscience, 2014
Cognitive deficits are common in Parkinson’s disease. Previous cross-sectional research has demonstrated a link between cognitive impairments and fronto-striatal dopaminergic dysmodulation. However, longitudinal studies that link disease progression with
Urban eEkman, Johan eEriksson, Lars eForsgren, Magdalena Eriksson Domellöf, Eva eElgh, Anders eLundquist, Lars eNyberg   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease [PDF]

, 2010
The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail.
Bartley, Máiréad, Lamberton, Franck, O'Neill, Des, D Rónán Collins, David Prvulovic, O'Dwyer, Laurence, D. Rónán Collins, Collins, D Rónán, Máiréad Bartley, Faluyi, Yetunde O., Harald Hampel, Bokde, Arun L. W., Mazoyer, Bernard M., Mazoyer, Bernard, Yetunde O. Faluyi, Hampel, Harald, Bokde, Arun L W, Laurence O'Dwyer, Arun L. W. Bokde, Prvulovic, David, Michael Ewers, Ewers, Michael, Faluyi, Yetunde O, Colby Tanner, Tanner, Colby, Franck Lamberton, Collins, D. Rónán, Coughlan, Tara, Des O'Neill, Arun L W Bokde, Yetunde O Faluyi, Bernard Mazoyer, Tara Coughlan   +32 more
core   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source