Results 71 to 80 of about 284,848 (306)

Assessment of outcome in clinical trials in mild Alzheimer 19s disease: urgent time for a rethink? [PDF]

, 2013
Introduction: A major barrier for clinical trials in Alzheimer's disease is the lack of sensitive clinical endpoints for the early stages. Until recently, regulatory agencies have required demonstration of improvement in two disease domains, cognition ...
McGoldrick, S., Duffy, Fiona, McGoldrick, Susan, Reynish, Emma, Kelly, Fiona, Morrison, Y., Wilson, L., Bennett, Crispin, Wilson, J T Lindsay, Bennett, C., Morrison, Yvonne, Duffy, F., Reynish, E.   +12 more
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Considering the base rates of low performance in cognitively healthy older adults improves the accuracy to identify neurocognitive impairment with the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB) [PDF]

, 2015
It is common for some healthy older adults to obtain low test scores when a battery of neuropsychological tests is administered, which increases the risk of the clinician misdiagnosing cognitive impairment.
Grant L. Iverson, Panagiota Mistridis, Klaus Willmes, Simone C. Egli, Manfred Berres, Iverson, Grant L., Berres, Manfred, Monsch, Andreas U., Egli, Simone C., Welsh-Bohmer, Kathleen A., Andreas U. Monsch, Willmes, Klaus, Iverson, Grant, Mistridis, Panagiota, Kathleen A. Welsh-Bohmer   +14 more
core   +1 more source

Functional Hubs in Mild Cognitive Impairment [PDF]

International Journal of Bifurcation and Chaos, 2015
We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients
Adrián Navas, David Papo, Stefano Boccaletti, Francisco del Pozo, Ricardo Bajo, Fernando Maestú, Johann H. Martínez, Pablo Gil, Irene Sendiña-Nadal, Javier M. Buldú   +9 more
openaire   +3 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Threshold effects of insulin resistance on cognitive function in coronary heart disease: the non-linear diagnostic value of the triglyceride-glucose index

Frontiers in Cardiovascular Medicine
BackgroundInsulin resistance contributes to cognitive dysfunction in patients with coronary heart disease (CHD). We examined the dose-response relationship between the triglyceride-glucose (TyG) index and cognitive status in this population.MethodsWe ...
Shun Zhao, Yejing Zhao, Xiaohong Wu, Changjiang Li, Hongyu Peng   +4 more
doaj   +1 more source

The Risk of Incident Mild Cognitive Impairment and Progression to Dementia Considering Mild Cognitive Impairment Subtypes

Dementia and Geriatric Cognitive Disorders Extra, 2017
Background: It remains unclear how demographic and clinical characteristics are related to the risk of incident mild cognitive impairment (MCI) by its subtypes.
Tzeyu L. Michaud, Dejun Su, Mohammad Siahpush, Daniel L. Murman   +3 more
doaj   +1 more source

Modern aspects of diagnosis and treatment of mild cognitive impairment

Российский журнал гериатрической медицины, 2020
The study of cognitive impairments (CI) began with a more severe form- dementia, which is usually the result of a long-running pathological process. It is preceded by non-demented cognitive disorders (including mild cognitive impairment syndrome — MCI ...
A. B. Lokshina
doaj   +1 more source

Cognitive profiles of vascular and neurodegenerative MCI

, 2008
The objective of the thesis was to investigate the cognitive profiles of different types of mild cognitive impairment (MCI) and follow their course over time.
Nordlund, Arto
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CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Targeting brain, body and heart for cognitive health and dementia prevention [PDF]

, 2012
This report looks into the current research regarding dementia and Alzheimer\u27s disease prevention and offers ideas for possible future solutions. Prevention of dementia is the ultimate aim of a large, albeit under resourced, international ...
Elodie O'Connor, Maree Farrow
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